Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
| NCT ID | Title | Phase | Status | Enrollment | Velocity | Design | Start | Completion | Last Updated | Sites | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|
| NCT01587950 | The Effects of Potassium Nitrate in Reducing Dentinal Hypersensitivity | PHASE1 | COMPLETED | 12 | — | — | Feb 1, 2009 | Apr 1, 2009 | Apr 28, 2015 | 1 | United States |
Response to a constant jet of air applied to a hypersensitive tooth was evaluated using a 100 millimeter (mm) VAS pain response scale. According to this analog scale, pain response for stimulated tooth ranged from 0 (no pain) to 100 (intense pain). Change from baseline in pain response was calculated using VAS score immediately post treatment.
Response to a constant (duration, pressure, temperature, distance from target) jet of air applied to a hypersensitive tooth was evaluated using a 100 mm VAS pain response scale. According to this analog scale, pain response for stimulated tooth ranged from 0 (no pain) to 100 (intense pain). Change from baseline in pain response was calculated using VAS score at 10 minutes post treatment.
Response to a constant (duration, pressure, temperature, distance from target) jet of air applied to a hypersensitive tooth was evaluated using a 100 mm VAS pain response scale. According to this analog scale, pain response for stimulated tooth ranged from 0 (no pain) to 100 (intense pain). Change from baseline in pain response was calculated using VAS score at 20 minutes post treatment.
| Arm | Type | Description |
|---|---|---|
| Sterile water | PLACEBO_COMPARATOR | Participants to receive 250 microlitres (μL) of sterile water. |
| Potassium nitrate 5% solution | EXPERIMENTAL | Participants to receive 250 μL of potassium nitrate 5% solution. |
| Potassium nitrate 2.5% solution | EXPERIMENTAL | Participants to receive 250 μL of potassium nitrate 2.5% solution. |
| Name | Type | Description |
|---|---|---|
| Potassium Nitrate | DRUG | 250 μL of Potassium nitrate solution (either 5% or 2.5%) |
| Placebo | DRUG | Sterile Water |
Inclusion Criteria: * General Health and Oral Heath: Good general health and oral health with (in the opinion of the investigator) no clinically significant and relevant abnormalities of medical history. * Teeth: Presence of teeth in various locations in the mouth to determine stent success. Requir...