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Mo-Rez

Phase 1

Tumours, Gynecological | Small molecule | Oncology |GSK plc|Last Updated: Jul 7, 2026

Success Probability

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Market & Valuation

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Trial Design

RandomizedCONTROLLED
Total Trials1
Total Enrollment305

FDA Designations

No designations recorded

Clinical trial landscape

Mo-Rez · 1 trial · 1 indication

Phase 1 1
NCT06796907A Study of Mocertatug Rezetecan in Combination With Anti-cancer Therapies for Advanced Solid Tumors (BEHOLD-2)Tumours, Gynecological
RECRUITING305 Analytics
PHASE1RECRUITING
A Study of Mocertatug Rezetecan in Combination With Anti-cancer Therapies for Advanced Solid Tumors (BEHOLD-2)
Tumours, GynecologicalUnlock trial analytics

Study Endpoints

Primary Endpoints

Part A: Percentage of participants with dose limiting toxicities (DLTs)
Approximately 7 months
Part A: Number of participants with adverse events (AEs), immune-mediated adverse events (imAEs), adverse events of special interest (AESI), serious adverse events (SAEs) by Severity
Up to approximately 22 months
Part A: Number of participants with adverse events (AEs), immune-mediated adverse events (imAEs), adverse events of special interest (AESI), serious adverse events (SAEs) by Frequency
Up to approximately 22 months
Part B: Confirmed Objective Response Rate (ORR)
Up to approximately 37 months

ORR is defined as the percentage of participants with a best overall confirmed (BOR) of Partial Response (PR) or better per Response Evaluation Criteria in Solid Tumors (RECIST 1.1)

Secondary Endpoints

Part A: Confirmed Objective Response Rate (ORR)
Up to approximately 22 months
Parts A and B: Duration of response (DoR)
Up to approximately 37 months
Parts A and B: Progression-free survival (PFS)
Up to approximately 37 months
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Study Design & Arms

AllocationRANDOMIZED
MaskingNONE
ModelPARALLEL
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
Module 1 (Mo-Rez +Dostarlimab) Endometrial CancerEXPERIMENTAL -
Module 2 (Mo-Rez +/-Bevacizumab) Ovarian CancerEXPERIMENTAL -

Interventions

NameTypeDescription
Mo-RezDRUGMo-Rez will be administered intravenously (IV).
DostarlimabDRUGDostarlimab will be administered IV.
BevacizumabDRUGBevacizumab will be administered IV.
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Eligibility Criteria

Age Range18 Years to N/A
SexALL
Healthy VolunteersNo
Study Sites81

Inclusion Criteria: * Participants must be 18 years of age inclusive or older, at the time of signing the informed consent, or the legal age of consent in the jurisdiction in which the study is taking place. * Participant capable of giving signed informed consent including compliance with the requi...

Countries:United StatesArgentinaAustraliaBelgiumBrazilCanadaDenmarkFinlandFranceGermanyGreeceItalyJapanMexicoNetherlandsNorwayPanamaPolandSouth KoreaSpainSwedenTurkey (Türkiye)United Kingdom
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Recent Changes (Last 90 Days)

LOWJul 7, 2026NCT06796907lastUpdatePostDate: changed
LOWJul 7, 2026NCT06796907lastUpdatePostDate: changed

Frequently asked questions about Mo-Rez

What is Mo-Rez used for?

Mo-Rez is an investigational small molecule being developed for the treatment of tumours, including gynecological tumours. It is currently in Phase 1 clinical development and has not been approved by regulatory authorities.

Who makes Mo-Rez?

Mo-Rez is being developed by GSK plc, a biopharmaceutical company listed on the stock exchange under the ticker GSK. The company is conducting clinical trials to evaluate the safety and efficacy of this investigational drug.

What phase is Mo-Rez in?

Mo-Rez is currently in Phase 1 clinical development. It is an investigational drug, meaning it has not yet been approved for commercial use. The ongoing Phase 1 trial is actively recruiting participants to study the drug in combination with other anti-cancer therapies.

What clinical trials is Mo-Rez in?

Mo-Rez is being studied in a Phase 1 clinical trial with the identifier NCT06796907, titled 'A Study of Mocertatug Rezetecan in Combination With Anti-cancer Therapies for Advanced Solid Tumors (BEHOLD-2)'. This trial is recruiting participants with tumours, including gynecological tumours, and is enrolling approximately 305 patients across multiple countries.

Is Mo-Rez the same as Mocertatug Rezetecan?

Yes, Mo-Rez is also known as Mocertatug Rezetecan. The clinical trial NCT06796907, which studies this drug, uses the name Mocertatug Rezetecan in its title. Both names refer to the same investigational drug being developed by GSK.