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Live attenuated human rotavirus vaccine

Phase 3

Infections, Rotavirus | Monoclonal antibody | Infectious Disease |GSK plc|Last Updated: May 30, 2017

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindUNCONTROLLED
Total Trials2
Total Enrollment510

FDA Designations

No designations recorded

Clinical trial landscape

Live attenuated human rotavirus vaccine · 3 trials · 2 indications

Phase 3 3
NCT00289172Assess the Immunogenicity & Safety of 2 Doses of Oral Live Attenuated Human Rota(HRV)Vaccine in Healthy Infants in IndiaInfections, Rotavirus
COMPLETED360 Analytics
NCT00134732Study of 2 Doses of Oral Live Attenuated Human Rotavirus (HRV) Vaccine for the Prophylaxis of Rotavirus GastroenteritisInfections, Rotavirus
COMPLETED150 Analytics
NCT00169455Assess the Immunogenicity of the Human Rotavirus (HRV) Vaccine After Reconstitution Without Buffering Agent; & Evaluate the Immunogenicity, Reactogenicity & Safety of the Vaccine After Storage for 7 d at 37°C Following 2 Doses in Healthy InfantsRotavirus Gastroenteritis
COMPLETED450 Analytics
PHASE3COMPLETED
Assess the Immunogenicity & Safety of 2 Doses of Oral Live Attenuated Human Rota(HRV)Vaccine in Healthy Infants in India
Infections, RotavirusUnlock trial analytics
PHASE3COMPLETED
Study of 2 Doses of Oral Live Attenuated Human Rotavirus (HRV) Vaccine for the Prophylaxis of Rotavirus Gastroenteritis
Infections, RotavirusUnlock trial analytics
PHASE3COMPLETED
Assess the Immunogenicity of the Human Rotavirus (HRV) Vaccine After Reconstitution Without Buffering Agent; & Evaluate the Immunogenicity, Reactogenicity & Safety of the Vaccine After Storage for 7 d at 37°C Following 2 Doses in Healthy Infants
Rotavirus GastroenteritisUnlock trial analytics

Study Endpoints

Primary Endpoints

Percentage of seroconversion (anti-rota serum IgA) in children, after two doses of HRV vaccine versus two doses of placebo.
Percent who seroconverted (anti-rota serum IgA, 2 months post dose 2)
Percentage of subjects with vaccine take
At 2 months post-Dose 2

Secondary Endpoints

Fever, vomiting, diarrhea. Solicited symptoms. Unsolicited events. SAEs. Presence of rotavirus in GE stools.
Grade 2 and 3 fever, vomiting, diarrhea, solicited symptoms
Unsolicited events
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Study Design & Arms

AllocationRANDOMIZED
ModelPARALLEL
PurposePREVENTION

Interventions

NameTypeDescription
Live attenuated human rotavirus vaccineBIOLOGICAL -
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Eligibility Criteria

Age Range8 Weeks to 12 Weeks
SexALL
Healthy VolunteersYes
Study Sites4

"Inclusion criteria: * A male or female between, and including, 8 and 10 weeks of age at the time of the first vaccination. * Written informed consent obtained from the parent or guardian of the subject. * Free of obvious health problems as established by medical history and clinical examination be...

Countries:IndiaSouth KoreaThailand
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Frequently asked questions about Live attenuated human rotavirus vaccine

What is Live attenuated human rotavirus vaccine used for?

Live attenuated human rotavirus vaccine is an investigational vaccine being developed for the prophylaxis of rotavirus gastroenteritis and rotavirus infections. It is administered orally in healthy infants to prevent disease caused by rotavirus.

Who makes Live attenuated human rotavirus vaccine?

Live attenuated human rotavirus vaccine is being developed by GSK plc, a pharmaceutical company listed on the stock exchange under the ticker GSK.

What phase is Live attenuated human rotavirus vaccine in?

Live attenuated human rotavirus vaccine is in Phase 3 clinical development. It is an investigational vaccine and has not been approved by regulatory authorities. Clinical trials are completed, and it remains under evaluation.

What clinical trials is Live attenuated human rotavirus vaccine in?

Live attenuated human rotavirus vaccine has completed three Phase 3 trials: NCT00134732 in South Korea with 150 participants, NCT00169455 in Thailand with 450 participants, and NCT00289172 in India with 360 participants. All trials involved healthy infants aged 6 weeks or older.

How is Live attenuated human rotavirus vaccine administered?

Live attenuated human rotavirus vaccine is given orally as a liquid suspension. Clinical trials evaluated two doses of the vaccine in healthy infants to assess immunogenicity, reactogenicity, and safety.