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Levitra

Phase 3

Erectile Dysfunction | Small molecule | Other |GSK plc|Last Updated: Dec 16, 2014

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindPLACEBO_CONTROLLED
Total Trials2
Total Enrollment851
FDA Designations
No designations recorded
Clinical Trials (2)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00668005Evaluating the Efficacy and Safety of Vardenafil in Subjects With Erectile Dysfunction and HypertensionPHASE3 COMPLETED 388Feb 1, 2003Sep 1, 2003Dec 16, 2014 -
NCT00658177Study Evaluating the Efficacy and Safety of Flexible-dose Vardenafil in Subjects With Erectile DysfunctionPHASE3 COMPLETED 463Jun 1, 2003Feb 1, 2004Dec 2, 2014 -
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Study Endpoints
Primary Endpoints
Sexual Encounter Profile (SEP), questions 2 and 3
12 weeks
Sexual Encounter Profile Question 2
12 weeks
Secondary Endpoints
International Index of Erectile Function (IIEF) - EF (Erectile Function) domain
12 weeks
Global Assessment Questionnaire (GAQ)
12 weeks
Safety and tolerability
12 weeks
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Study Design & Arms
AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
Arm 1EXPERIMENTAL -
Arm 2PLACEBO_COMPARATOR -
Interventions
NameTypeDescription
Levitra (Vardenafil, BAY38-9456)DRUG5mg, 10mg or 20mg taken 1h before sexual intercourse
PlaceboDRUGMatching placebo
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Eligibility Criteria
Age Range18 Years — N/A
SexMALE
Healthy VolunteersNo

Inclusion Criteria: * Men \>/= 18 years of age, with 6 months or longer diagnosis of ED as defined by NIH Consensus statement, * Arterial hypertension adequately controlled * Stable sexual relationship for \> 6 month Exclusion Criteria: * Primary hypoactive sexual desire * History of myocardial i...

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