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Ipratropium · 2 trials · 1 indication
To correlate changes in oxygen saturation pre- and post- bronchodilator (as a reflection of ventilation/perfusion matching) with changes in distribution of regional ventilation/perfusion (V/Q) demonstrated by hyperpolarized helium ventilation MRI/spatially registered proton perfusion.
To correlate changes in oxygen saturation pre- and post- bronchodilator (as a reflection of ventilation/perfusion matching) with changes in distribution of regional ventilation/perfusion (V/Q) demonstrated by hyperpolarized helium ventilation MRI/spatially registered proton perfusion.
| Arm | Type | Description |
|---|---|---|
| Salbutamol + Ipratropium | OTHER | Treatment period 1: Salbutamol 5mg nebulised, single Dose. Treatment period 2: Ipratropium 500mcg nebulised, single dose. |
| Ipratropium + Salbutamol | OTHER | Treatment period 1: Ipratropium 500mcg nebulised, single dose. Treatment period 2: Salbutamol 5mg nebulised, single Dose. |
| Propranolol alone | EXPERIMENTAL | Propranolol 80 mg (5 doses at 6 hourly intervals) |
| Propranolol + salbutamol | EXPERIMENTAL | Propranolol 80 mg (5 doses at 6 hourly intervals) + salbutamol 600 μg (4 doses at 6 hourly intervals) |
| Salbutamol alone | EXPERIMENTAL | Salbutamol 600 μg (4 doses at 6 hourly) + placebo (5 doses at 6 hourly intervals) |
| Placebo | PLACEBO_COMPARATOR | Placebo (5 doses at 6 hourly) |
| Propranolol + ipratropium + salbutamol | EXPERIMENTAL | Propranolol 80 mg (2 doses at 6 hourly intervals) + ipratropium bromide 40 μg (2 doses at 6 hourly interval) + salbutamol 600 μg (1 dose) |
| Placebo + ipratropium + salbutamol | EXPERIMENTAL | Placebo (2 doses at 6 hourly intervals) + ipratropium bromide 40 μg (2 doses at 6 hourly interval) + salbutamol 600 μg (1 dose) |
| Name | Type | Description |
|---|---|---|
| He-3 MRI | DEVICE | Hyperpolarised helium-3 Magnetic Resonance Imaging (MRI) scan pre-bronchodilator and 1 hour post-bronchodilator (after 1 hour post-bronchodilator assessments/procedures completed). |
| Salbutamol | DRUG | Salbutamol 5mg nebulised single dose |
| Ipratropium | DRUG | Ipratropium 500mcg nebulised single dose |
| MRI | DEVICE | Proton Magnetic Resonance Imaging (MRI) scan pre-bronchodilator and 1 hour post-bronchodilator (after 1 hour post-bronchodilator assessments/procedures completed). |
| Propranolol | DRUG | 40 mg tablets |
| Placebo | DRUG | Placebo for propranolol tablets |
Inclusion Criteria: \- Diagnosis of Chronic Obstructive Pulmonary Disease (COPD) diagnosis: an established clinical history of chronic pulmonary disorder in accordance with the following description by the American Thoracic Society / European Respiratory Society \[ATS / ETS, 2004\] Chronic obstruc...