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GW815SF Salmeterol/Fluticasone propionate

Phase 3

Bronchial Asthma | Small molecule | Respiratory |GSK plc|Last Updated: May 6, 2015

Success Probability

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Market & Valuation

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Trial Design

UNCONTROLLED
Total Trials1
Total Enrollment40

FDA Designations

No designations recorded

Clinical trial landscape

GW815SF Salmeterol/Fluticasone propionate · 1 trial · 1 indication

Phase 3 1
NCT00449046Clinical Assessment Of GW815SF Salmeterol/Fluticasone Propionate(HFA MDI) In Pediatric Patients With Bronchial Asthma -A Long Term (24-week) Study-Bronchial Asthma
COMPLETED40 Analytics
PHASE3COMPLETED
Clinical Assessment Of GW815SF Salmeterol/Fluticasone Propionate(HFA MDI) In Pediatric Patients With Bronchial Asthma -A Long Term (24-week) Study-
Bronchial AsthmaUnlock trial analytics

Study Endpoints

Primary Endpoints

Most Frequent Adverse Events - On Therapy
Baseline to Week 24

Adverse events, Clinical laboratory tests, Adrenocortical function test, Physical examinations, 12-lead electrocardiogram (ECG), Oropharyngeal examination were included.

Serious Adverse Events (SAEs) - On Therapy
Baseline to Week 24

Number of participants considered by the investigator to be related to study medication. Adverse events, Clinical laboratory tests, Adrenocortical function test, Physical examinations, 12-lead ECG, Oropharyngeal examination were included. Frequency threshold of reported SAE's is 0%(100% reported)

Secondary Endpoints

Change From Baseline in Morning Peak Expiratory Flow (PEF) During Weeks 1-24
Baseline and during Weeks 1-24
Change From Baseline in Percent Predicted Morning Peak Expiratory Flow (PEF) During Weeks 1-24
Baseline and during Weeks 1-24
Change From Baseline in Evening Peak Expiratory Flow (PEF) During Weeks 1-24
Baseline and during Weeks 1-24
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Study Design & Arms

AllocationNON_RANDOMIZED
MaskingNONE
ModelSINGLE_GROUP
PurposeTREATMENT

Interventions

NameTypeDescription
GW815SF Salmeterol/Fluticasone propionate(HFA MDI)DRUG -
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Eligibility Criteria

Age Range5 Years to 14 Years
SexALL
Healthy VolunteersNo
Study Sites3

Inclusion criteria: * Inclusion Criteria for Entry in Run-in Period A pediatric patient already diagnosed as having bronchial asthma who meets all of the following criteria is eligible for the study: * Male or female patients aged ≥5 and ≤14 years. Enrolment of a female patient of childbearing po...

Countries:Japan
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Frequently asked questions about GW815SF Salmeterol/Fluticasone propionate

What is GW815SF Salmeterol/Fluticasone propionate used for?

GW815SF Salmeterol/Fluticasone propionate is used for the treatment of bronchial asthma. It is a combination product being developed by GSK plc for this respiratory condition. The drug is currently in Phase 3 clinical development and is intended for pediatric patients with bronchial asthma.

What does GW815SF Salmeterol/Fluticasone propionate target?

GW815SF Salmeterol/Fluticasone propionate is a combination of two active ingredients: salmeterol, a long-acting beta-agonist, and fluticasone propionate, an inhaled corticosteroid. These components work together to provide bronchodilation and reduce airway inflammation in patients with bronchial asthma.

Who makes GW815SF Salmeterol/Fluticasone propionate?

GW815SF Salmeterol/Fluticasone propionate is being developed by GSK plc, a global pharmaceutical company listed on the stock exchange under the ticker GSK. The company is conducting clinical trials to evaluate this combination therapy for the treatment of bronchial asthma.

What phase is GW815SF Salmeterol/Fluticasone propionate in?

GW815SF Salmeterol/Fluticasone propionate is in Phase 3 clinical development. It is an investigational drug and has not yet been approved by regulatory authorities. A Phase 3 clinical trial has been completed to assess its safety and efficacy in pediatric patients with bronchial asthma.

What clinical trials is GW815SF Salmeterol/Fluticasone propionate in?

GW815SF Salmeterol/Fluticasone propionate has one completed clinical trial, identified as NCT00449046. This was a Phase 3, long-term (24-week) study conducted in Japan, enrolling 40 pediatric patients aged 5 years and older with bronchial asthma. The trial was uncontrolled and not randomized or double-blinded.

Is GW815SF Salmeterol/Fluticasone propionate the same as other salmeterol/fluticasone products?

GW815SF Salmeterol/Fluticasone propionate is a specific formulation of the combination of salmeterol and fluticasone propionate, delivered via a hydrofluoroalkane (HFA) metered-dose inhaler. It is being studied for pediatric use in Japan and is distinct from other marketed combination products of these two drugs.