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GW597599

Phase 2

Sleep Disorders | Small molecule | Other |GSK plc|Last Updated: Oct 28, 2016

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindPLACEBO_CONTROLLEDBiomarker
Total Trials1
Total Enrollment161
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00992160Vestipitant 28-day Tolerance StudyPHASE2 COMPLETED 161May 1, 2009Sep 1, 2009Oct 28, 201613 Germany
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Study Endpoints
Primary Endpoints
Nocturnal polysomngraphy
6 weeks after start of treatment
Secondary Endpoints
Subjective sleep assessments as performed by Post-Sleep Questionnaires and subject -rated Insomnia Severity Index
4 weeks after start of treatment
Motor and cognitive functioning assessed by neurological tests (Romberg and Hee-to-toe) and Cognitive tests (Digit Symbol Substitution test and verbal Learning Memory test)
4 weeks after start of treatment
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Study Design & Arms
AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
ActiveEXPERIMENTALVestipitant 15mg once daily
PlaceboPLACEBO_COMPARATORPlacebo
Interventions
NameTypeDescription
GW597599DRUGGW597599 15mg tablet
PlaceboDRUGPlacebo to match GW597599 15mg tablet
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Eligibility Criteria
Age Range18 Years — 64 Years
SexALL
Healthy VolunteersNo
Study Sites13

Inclusion Criteria: * Male and female aged 18-64 years inclusively with Diagnosis of Primary Insomnia according to Diagnostic and Statistical Manual of Mental Disorders -Text Revision (DSM-IV-TR) criteria 307.42 * PSG variables collected during 2consecutive PSG screening nights falling as follows: ...

Countries:Germany
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