Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
| NCT ID | Title | Phase | Status | Enrollment | Velocity | Design | Start | Completion | Last Updated | Sites | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|
| NCT00379990 | A Study To Investigate GW274150 Or Prednisolone In Rheumatoid Arthritis Taken Repeatedly For 28 Days. | PHASE2 | COMPLETED | 48 | — | — | Jan 1, 2006 | Dec 1, 2007 | Jul 2, 2012 | 2 | Serbia, United Kingdom |
| NCT00370435 | Study Of 90mg Of GW274150 In Subjects Over 50 Years, Who Have Rheumatoid Arthritis (RA) | PHASE2 | COMPLETED | 6 | — | — | Aug 1, 2005 | Sep 1, 2005 | May 30, 2017 | 1 | United Kingdom |
Power Doppler ultrasonographic measurement of synovial vascularity
| Arm | Type | Description |
|---|---|---|
| GW274150 60 mg once daily for 28 days | EXPERIMENTAL | 60 mg GW274150 taken once daily for 28 days |
| Prednisolone 7.5 mg once daily for 28 days | ACTIVE_COMPARATOR | 7.5 mg prednisolone taken once daily for 28 days |
| Placebo once daily for 28 days | PLACEBO_COMPARATOR | Placebo taken once daily for 28 days |
| Name | Type | Description |
|---|---|---|
| GW274150 | DRUG | 60 mg /day |
| Prednisolone | DRUG | 7.5 mg/day |
| Placebo | OTHER | Placebo |
Inclusion criteria: * Diagnosis of rheumatoid arthritis according to the revised 1987 criteria of the American College of Rheumatology * Female subjects who are not capable of becoming pregnant * Active disease defined as Disease Activity Score (DAS) 28 = 4.0 and at least one metacarpal-phalangeal ...