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GSK5458514

Phase 1

Neoplasms, Prostate | Small molecule | Oncology |GSK plc|Last Updated: Jun 18, 2026

Success Probability

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Market & Valuation

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Trial Design

RandomizedCONTROLLED
Total Trials1
Total Enrollment85

FDA Designations

No designations recorded

Clinical trial landscape

GSK5458514 · 1 trial · 1 indication

Phase 1 1
NCT06990880A Study of GSK5458514 Administered Alone or In Combination With Other Anti-Cancer Agents in Participants With Prostate CancerNeoplasms, Prostate
RECRUITING85 Analytics
PHASE1RECRUITING
A Study of GSK5458514 Administered Alone or In Combination With Other Anti-Cancer Agents in Participants With Prostate Cancer
Neoplasms, ProstateUnlock trial analytics

Study Endpoints

Primary Endpoints

Number of participants with dose limiting toxicities (DLTs) during DLT observation period
Up to 28 days
Number of participants with adverse events (AEs), serious adverse events (SAEs), by Severity
Up to approximately 29 months
Number of participants with AEs leading to dose modifications
Up to approximately 29 months

Secondary Endpoints

Area under concentration from 0 to t (AUC 0-t) of GSK5458514
Up to approximately 32 months
Maximum concentration (Cmax) of GSK5458514
Up to approximately 32 months
Time to reach maximum concentration (Tmax) of GSK5458514
Up to approximately 32 months
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Study Design & Arms

AllocationRANDOMIZED
MaskingNONE
ModelSEQUENTIAL
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
Part 1: Dose escalation of GSK5458514 monotherapyEXPERIMENTAL -
Part 2: Dose expansion of GSK5458514 monotherapyEXPERIMENTAL -

Interventions

NameTypeDescription
GSK5458514DRUGGSK5458514 will be administered.
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Eligibility Criteria

Age Range18 Years to N/A
SexMALE
Healthy VolunteersNo
Study Sites19

Inclusion Criteria: * Provide signed informed consent. Participants must be capable of providing informed consent, which includes compliance with the requirements and restrictions listed in the ICF and in this protocol. * Male participants ≥18 years of age (or the legal age of consent in the jurisd...

Countries:United StatesCanadaFranceJapanSpain
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Recent Changes (Last 90 Days)

LOWJun 18, 2026NCT06990880lastUpdatePostDate: changed
LOWJun 18, 2026NCT06990880lastUpdatePostDate: changed
LOWJun 18, 2026NCT06990880lastUpdatePostDate: changed

Frequently asked questions about GSK5458514

What is GSK5458514 used for?

GSK5458514 is an investigational small molecule being studied for the treatment of prostate cancer, specifically for neoplasms of the prostate. It is currently in Phase 1 clinical development and is not yet approved by regulatory authorities.

Who is developing GSK5458514?

GSK5458514 is being developed by GSK plc, a global biopharmaceutical company traded on the London Stock Exchange under the ticker GSK. The company is conducting clinical trials to evaluate the safety and efficacy of this investigational drug in patients with prostate cancer.

What phase is GSK5458514 in?

GSK5458514 is currently in Phase 1 clinical development. This early-stage trial is designed to assess the safety, tolerability, and preliminary efficacy of the drug in participants with prostate cancer. The drug is investigational and has not been approved for commercial use.

What clinical trials is GSK5458514 in?

GSK5458514 is being evaluated in a Phase 1 clinical trial registered as NCT06990880. This study, which is currently recruiting participants, is investigating the drug administered alone or in combination with other anti-cancer agents in patients with prostate cancer. The trial is expected to enroll approximately 85 participants across the United States, Canada, France, Japan, and Spain.

Is GSK5458514 FDA approved?

No, GSK5458514 is not FDA approved. It is an investigational drug currently in Phase 1 clinical trials for prostate cancer. The drug has not yet completed the clinical development process required to obtain regulatory approval from the FDA or other health authorities.