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GSK206136

Phase 1

Depressive Disorder and Anxiety Disorders | Small molecule | Psychiatry |GSK plc|Last Updated: Aug 10, 2017

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindPLACEBO_CONTROLLED
Total Trials1
Total Enrollment33

FDA Designations

No designations recorded

Clinical trial landscape

GSK206136 · 1 trial · 1 indication

Phase 1 1
NCT01059578First Study in Humans With GSK206136Depressive Disorder and Anxiety Disorders
COMPLETED33 Analytics
PHASE1COMPLETED
First Study in Humans With GSK206136
Depressive Disorder and Anxiety DisordersUnlock trial analytics

Study Endpoints

Primary Endpoints

Adverse event monitoring, vital signs (blood pressure, heart rate, ECGs, clinical laboratory assessments (standard laboratory parameters); pharmacokinetics parameters: AUC, Cmax, t1/2
12 weeks

Secondary Endpoints

Brain receptor occupancy
2 weeks
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Study Design & Arms

AllocationRANDOMIZED
MaskingDOUBLE
ModelCROSSOVER
PurposeBASIC_SCIENCE

Treatment Arms

ArmTypeDescription
ActiveEXPERIMENTALGSK206136 once daily
PlaceboPLACEBO_COMPARATORPlacebo once daily

Interventions

NameTypeDescription
GSK206136DRUGGSK206136 2mg, 10mg, 50mg, 100mg capsule
PLACEBODRUGPlacebo to match 206136 2mg, 10mg, 50mg, 100mg capsule
PETRADIATIONEach subject will undergo 3 PET Scans ; one at Baseline and the others following dosing with GSK206136 at approximately 2 hours post-dose and 24 hours post-dose
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Eligibility Criteria

Age Range18 Years to 45 Years
SexMALE
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * Healthy males aged 18-45 years, limited to 25-40 years of age for PET section Exclusion Criteria: * The subject has a positive: drug/alcohol, Hepatitis, HIV screen.. * The subject has a history of psychiatric illness suicidal attempts or behaviour. * Abuse of alcohol. * Clin...

Countries:United Kingdom
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Frequently asked questions about GSK206136

What is GSK206136 used for?

GSK206136 is an investigational small molecule being studied for the treatment of Depressive Disorder and Anxiety Disorders. It is in Phase 1 clinical development and has not been approved by regulatory authorities.

Who makes GSK206136?

GSK206136 is being developed by GSK plc, a pharmaceutical company traded on the stock exchange under the ticker GSK.

What phase is GSK206136 in?

GSK206136 is in Phase 1 clinical development. It is an investigational drug and has not been approved for any use. A Phase 1 study has been completed.

What clinical trials is GSK206136 in?

GSK206136 has one completed Phase 1 trial, NCT01059578, titled 'First Study in Humans With GSK206136'. This trial enrolled 33 participants in the United Kingdom and was a randomized, double-blind, placebo-controlled study.

Is GSK206136 the same as any other drug?

No alternative names for GSK206136 have been reported. It is identified solely by its code name GSK206136 in clinical trial records.