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GR68755

Phase 2

Irritable Colon | Small molecule | Other |GSK plc|Last Updated: May 1, 2017

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
UNCONTROLLEDBiomarker
Total Trials1
Total Enrollment32
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT01855711Safety and Efficacy Study of GR68755 (Alosetron Hydrochloride) to Treat Severe Diarrhea-Predominant Irritable Bowel Syndrome (IBS)PHASE2 COMPLETED 32Sep 18, 2003May 10, 2005May 1, 2017 -
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Study Endpoints
Primary Endpoints
Global Improvement Scale(GIS)
four weeks
Satisfactory control of IBS related bowel urgency
four weeks
Secondary Endpoints
Adequate relief of IBS pain and discomfort
four weeks
Days without abdominal pain and discomfort
four weeks
Severity score of abdominal pain and/or discomfort
four weeks
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Study Design & Arms
AllocationNA
MaskingNONE
ModelSINGLE_GROUP
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
GR68755 (Alosetron hydrochrolide) groupEXPERIMENTALGR68755 1 mg tablets QD in the morning every day for 28 days
Interventions
NameTypeDescription
GR68755 (Alosetron hydrochloride) 1 mg tabletDRUG1 tablet (1 mg) once a day
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Eligibility Criteria
Age Range20 Years — 64 Years
SexFEMALE
Healthy VolunteersNo

Inclusion Criteria: A subject will be eligible for inclusion in this study only if all of the following criteria apply: 1. Disease to be treated: Has been diagnosed with severe d-IBS (at least 6 months of d-IBS symptoms as defined by the Rome II Criteria), and failed conventional IBS therapy. ...

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