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Engerix

Phase 3

Infections, Papillomavirus | Monoclonal antibody | Other |GSK plc|Last Updated: Jan 3, 2020

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedACTIVE_CONTROLLED
Total Trials1
Total Enrollment152
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00637195Immunogenicity and Safety of a Commercially Available Vaccine Co-administered With GSK HPV Vaccine (580299)PHASE3 COMPLETED 152Mar 11, 2008Jun 18, 2009Jan 3, 20202 Belgium
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Study Endpoints
Primary Endpoints
Number of Subjects Seroprotected Against Hepatitis B Following 3 Doses of Engerix
Month 3

A subject seroprotected against hepatitis B is a subject with anti-hepatitis B surface antigen (HBs) antibody titers greater than or equal to 10 milli-international units per milliliter (mIU/mL).

Anti-hepatitis B Surface Antigen (HBs) Antibody Titers Following 3 Doses of Engerix
Month 3

Titers are given as Geometric Mean Titers (GMTs) expressed as milli-international units per milliliter (mIU/mL).

Secondary Endpoints
Number of Subjects Seroconverted for Anti-human Papilloma Virus 16 and 18 (Anti-HPV-16 and Anti-HPV-18) Antibodies
Months 2 and 7
Anti-HPV-16/18 Antibody Titers
Months 2 and 7
Number of Subjects Seroconverted for Anti-hepatitis B (HBs) Antibodies
Months 2, 3 and 13
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Study Design & Arms
AllocationRANDOMIZED
MaskingNONE
ModelPARALLEL
PurposePREVENTION
Treatment Arms
ArmTypeDescription
Cervarix™ & Engerix™ GroupEXPERIMENTALSubjects received 3 doses of GSK Biologicals' HPV vaccine (580299) (Cervarix™) (Months 0, 1 \& 6) and 4 doses of Hepatitis B (Engerix™) vaccine (Months 0, 1, 2 \& 12).
Engerix™ GroupACTIVE_COMPARATORSubjects received 4 doses of Hepatitis B (HBV) vaccine (Months 0, 1, 2 \& 12).
Interventions
NameTypeDescription
Subjects received 3 doses of GSK Biologicals' HPV vaccine (580299) (Cervarix™)BIOLOGICALIntramuscular administration, 3 doses.
Engerix™BIOLOGICALIntramuscular administration, 4 doses.
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Eligibility Criteria
Age Range20 Years — 25 Years
SexFEMALE
Healthy VolunteersYes
Study Sites2

Inclusion Criteria: * Subjects who the investigator believes that they can and will comply with the requirements of the protocol should be enrolled in the study. * A female between, and including, 20 and 25 years of age at the time of the first vaccination. * Written informed consent obtained from ...

Countries:Belgium
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