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Eccentric exercise · 1 trial · 1 indication
Muscle strength is a measure the amount of force produced during a maximal voluntary contraction. Strength will be assessed by a maximal isometric (fixed length) contraction.
| Arm | Type | Description |
|---|---|---|
| Arm 1 | OTHER | Healthy subjects aged 18 to 35 years |
| Name | Type | Description |
|---|---|---|
| Eccentric exercise | OTHER | Each subject will perform eccentric exercise against a predefined personal maximal strength of their non-dominant leg on day 1. Changes on strength, biomarker concentrations and muscle protein synthesis during damage and recovery will be measured over 22 days. |
Inclusion Criteria: * Males aged between 18 and 35 years of age inclusive, at the time of signing the informed consent, not on a regular exercise program. * Body Mass Index (BMI) 18-27 kilogram per meter square (kg/m\^2) with waist circumference \<96 centimeter (cm). * Healthy as determined by a re...
Eccentric exercise is an investigational intervention being studied for the management of tendon injuries. It is a form of exercise that involves lengthening a muscle while it is under tension. The intervention is currently in Phase 1 clinical development, with one completed trial involving 12 participants in the United Kingdom.
Eccentric exercise is being developed by GSK plc, a global biopharmaceutical company listed on the stock exchange under the ticker symbol GSK. The company is conducting clinical research to evaluate the intervention's effects in the context of tendon injuries, with the development program currently in the Phase 1 stage.
Eccentric exercise is in Phase 1 clinical development. It is an investigational intervention and has not been approved by regulatory authorities. The Phase 1 program includes one completed trial that assessed muscle damage after eccentric exercise in healthy volunteers, with a total enrollment of 12 participants.
Eccentric exercise has one completed clinical trial registered under NCT02014662, titled "A Methodology Study to Assess Muscle Damage After Eccentric Exercise." This Phase 1 trial was conducted in the United Kingdom, enrolled 12 healthy male participants aged 18 years and older, and focused on tendon injuries.
Eccentric exercise is a distinct intervention and is not known to be the same as any other named treatment. It is a specific type of exercise regimen being evaluated for its potential role in tendon injuries. No alternative names have been associated with this intervention in the available clinical trial information.