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ELLIPTA, DISKUS

Phase 3

Pulmonary Disease, Chronic Obstructive | Unknown | Other |GSK plc|Last Updated: Mar 4, 2014

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedCONTROLLEDBiomarker
Total Trials1
Total Enrollment287
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT01868009DISKUS vs. ELLIPTA Device Preference Study in Chronic Obstructive Pulmonary Disease (COPD)PHASE3 COMPLETED 287May 1, 2013Jul 1, 2013Mar 4, 201417 United States
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Study Endpoints
Primary Endpoints
Number of Participants With the Indicated Device Preference Based on the Size of the Numbers on the Dose Counter
up to Study Day 26

The number of participants who expressed the indicated device preference (i.e., preference for ELLIPTA inhaler, preference for DISKUS inhaler, and no preference) based on the size of the numbers on the dose counter was summarized by study inhaler use sequence.

Secondary Endpoints
Number of Participants With the Indicated Device Preference Based on the Number of Steps Needed to Take the COPD Medication
up to Study Day 26
Number of Participants With the Indicated Device Preference Based on the Size of the Device
up to Study Day 26
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Study Design & Arms
AllocationRANDOMIZED
MaskingNONE
ModelCROSSOVER
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
ELLIPTA Period 1 and DISKUS Period 2 ArmEXPERIMENTALSubjects will use the ELLIPTA inhaler once daily for 5 to 9 days during the first period followed by the DISKUS inhaler twice daily for 5 to 9 days during the second period.
DISKUS Period 1 and ELLIPTA Period 2 ArmEXPERIMENTALSubjects will use the DISKUS inhaler twice daily for 5 to 9 days during the first period followed by the ELLIPTA inhaler once daily for 5 to 9 days during the second period.
Interventions
NameTypeDescription
ELLIPTADEVICENovel dry powder inhaler (placebo) with 30 doses (2 strips with 30 blisters per strip)
DISKUSDEVICEMultidose dry powder inhaler (placebo) containing a foil strip worth 60 blisters (1 strip with 60 blisters per strip)
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Eligibility Criteria
Age Range40 Years — N/A
SexALL
Healthy VolunteersNo
Study Sites17

Inclusion Criteria: * 1\. Informed consent * Subject must give their signed and dated written informed consent to participate. * Subject understands and is willing, able, and likely to comply with study procedures and restrictions. * Subject must be able to read, comprehend, and record information ...

Countries:United States
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