Approval Probability
TA Base Rate
Adjusted LOA
ML Risk
Creatine · 1 trial · 1 indication
Change in PCr concentration (at rest), as measured by 31P- MRS on the calf. Static MRS will be acquired at rest up to 2 min.
| Arm | Type | Description |
|---|---|---|
| Creatine Group | EXPERIMENTAL | Whey protein (30 g) and creatine supplement (5 g) shaken with 250-300 ml water in a blender bottle, and the full shake to be taken twice a day for 14 days. |
| Placebo Group | PLACEBO_COMPARATOR | Whey protein (30 g) and bulking agent powder (5 g) shaken with 250-300 ml water in a blender bottle, and the full shake to be taken twice a day for 14 days. |
| Name | Type | Description |
|---|---|---|
| Creatine | DRUG | Creatine powder (5 g) |
| Placebo | DRUG | Bulking agent powder (5 g) |
Inclusion Criteria: * Healthy volunteer: Group 1: male; Group 2: male or female. * Aged 18-35 years (Group 1), or 50-70 years (Group 2). * Dietary protein intake at or near the current recommended daily amount (0.75 to 0.85 g protein/kg/day). * Participation in regular physical activity (aerobic an...
Creatine is being studied for its effects on nutritional status, specifically to investigate the effects of creatine supplementation on muscle energetics and cognitive function in young healthy male athletes and an ageing population. It is currently in Phase 1 clinical development as an investigational small molecule.
Creatine is being developed by GSK plc, a biopharmaceutical company traded on the stock exchange under the ticker GSK. The company is conducting clinical research to evaluate the supplement's effects on muscle energetics and cognitive function.
Creatine is in Phase 1 clinical development. It is an investigational drug and has not been approved by regulatory authorities. The Phase 1 trial has been completed, and the drug remains under investigation for its effects on nutritional status.
Creatine has one completed clinical trial registered as NCT02058654. This Phase 1 study investigated the effects of creatine supplementation on muscle energetics and cognitive function in young healthy male athletes and an ageing population. The trial enrolled 30 participants in the United Kingdom.
Creatine is a small molecule supplement being studied for its effects on nutritional status. The clinical trial NCT02058654 evaluates creatine supplementation, which typically refers to creatine monohydrate, a common form used in dietary supplements. However, the specific form used in the trial is not detailed.