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Synthetic MVA-based SARS-CoV-2 Vaccine COH04S1

Phase 2

COVID-19 Infection | Monoclonal antibody | Infectious Disease |GeoVax Labs, Inc.|Last Updated: Feb 9, 2026

Success Probability

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Trial Design

UNCONTROLLED
Total Trials1
Total Enrollment119

FDA Designations

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Clinical trial landscape

Synthetic MVA-based SARS-CoV-2 Vaccine COH04S1 · 1 trial · 1 indication

Phase 1/2 1
NCT04639466A Synthetic MVA-based SARS-CoV-2 Vaccine, GEO-CM04S1, for the Prevention of COVID-19 InfectionCOVID-19 Infection
COMPLETED119 Analytics
PHASE1/PHASE2COMPLETED
A Synthetic MVA-based SARS-CoV-2 Vaccine, GEO-CM04S1, for the Prevention of COVID-19 Infection
COVID-19 InfectionUnlock trial analytics

Study Design & Arms

Interventions

NameTypeDescription
Placebo AdministrationDRUGGiven IM in the non-dominant upper arm
Synthetic MVA-based SARS-CoV-2 Vaccine COH04S1BIOLOGICALGiven IM in the non-dominant upper arm
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Frequently asked questions about Synthetic MVA-based SARS-CoV-2 Vaccine COH04S1

What is COH04S1 used for?

COH04S1, also known as GEO-CM04S1, is a synthetic MVA-based SARS-CoV-2 vaccine being developed for the prevention of COVID-19 infection. It is currently in Phase 2 clinical development as an investigational vaccine.

Who makes COH04S1?

COH04S1 is being developed by GeoVax Labs, Inc., a biopharmaceutical company traded on the NASDAQ under the ticker symbol GOVX. The vaccine is also referred to as GEO-CM04S1 in clinical trial documentation.

What phase is COH04S1 in?

COH04S1 is in Phase 2 clinical development for the prevention of COVID-19 infection. It is an investigational vaccine and has not been approved by regulatory authorities. One clinical trial has been completed, which was a Phase 1/Phase 2 study.

What clinical trials is COH04S1 in?

COH04S1 has been studied in one clinical trial with the identifier NCT04639466, titled "A Synthetic MVA-based SARS-CoV-2 Vaccine, GEO-CM04S1, for the Prevention of COVID-19 Infection." This Phase 1/Phase 2 trial enrolled 119 participants and has been completed.

Is COH04S1 the same as GEO-CM04S1?

Yes, COH04S1 is the same as GEO-CM04S1. The vaccine is referred to by both names, with GEO-CM04S1 being the name used in the clinical trial title for the study NCT04639466.