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EVO101

Phase 1

Hidradenitis Suppurativa (HS) | Small molecule | Dermatology |Evommune, Inc.|Last Updated: Dec 11, 2024

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
Premium
Trial Design
UNCONTROLLEDDMCBiomarker
Total Trials1
Total Enrollment15
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT06645821Participants with Mild to Moderate Hidradenitis Suppurativa Will Receive EVO101 a Topical Cream 0.1%EARLY_PHASE1 RECRUITING 15Dec 3, 2024May 1, 2025Dec 11, 20241 United States
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Study Endpoints
Primary Endpoints
The efficacy of EVO101 on hidradenitis suppurativa will be evaluated using two parameters: decrease in lesion count and change in patient reported outcomes (PRO)
12 Weeks

The change in the total HS lesion count will be assessed at Week 4, Week 8, and Week 12. The percent change from Baseline will be calculated.

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Study Design & Arms
AllocationNA
MaskingNONE
ModelSINGLE_GROUP
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
Open label EVO101 topical cream 0.1%EXPERIMENTALAll eligible subjects will receive open label EVO101 topical cream 0.1%
Interventions
NameTypeDescription
EVO101DRUGEVO101 topical cream 0.1%
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Eligibility Criteria
Age Range18 Years — N/A
SexALL
Healthy VolunteersNo
Study Sites1

Inclusion Criteria: 1. Ability to comprehend and willingness to sign a written informed consent form (ICF) for the study. 2. Age ≥ 18 years at the time of signing the ICF (informed consent). 3. Diagnosis of hidradenitis suppurativa (HS) for at least 3 months prior to the screening visit. 4. Mild to...

Countries:United States
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Recent Changes (Last 90 Days)
LOWMay 26, 2026NCT06645821primaryCompletionDate: changed
LOWMay 24, 2026NCT06645821studyFirstPostDate: changed