Approval Probability
TA Base Rate
Adjusted LOA
ML Risk
Histamine · 1 trial · 1 indication
| Arm | Type | Description |
|---|---|---|
| TOLAMBA™ | ACTIVE_COMPARATOR | - |
| Histamine | SHAM_COMPARATOR | Histamine simulates mild redness/swelling effect seen with active comparator, TOLAMBA™. Prevents study staff from easily identifying subjects who received active comparator. |
| Name | Type | Description |
|---|---|---|
| Amb a 1 Immunostimulatory Oligoribonucleotide Conjugate | BIOLOGICAL | 6 weekly subcutaneous injections (escalating doses of 3 mcg to 30 mcg) |
| Histamine | DRUG | 6 weekly subcutaneous injections (escalating doses of 0.22 mcg to 1.1 mcg) |
Inclusion Criteria: * Is willing and able to give signed informed consent, and must have provided this consent. * Has a clinical history of seasonal allergic rhinitis with seasonal nasal allergy symptoms during each of the last 2 ragweed allergy seasons. * Has documentation of a positive skin test ...
Histamine is an investigational small molecule being developed for the treatment of seasonal allergic rhinitis. It is currently in Phase 2 clinical development, meaning it has not yet been approved and is still being studied for safety and efficacy in patients.
Histamine is being developed by Dynavax Technologies Corporation, a biopharmaceutical company traded on the NASDAQ under the ticker symbol DVAX. The company is conducting clinical trials to evaluate the drug's potential in treating seasonal allergic rhinitis.
Histamine is currently in Phase 2 clinical development. It is an investigational drug, meaning it has not been approved by regulatory authorities. The drug is being studied for the treatment of seasonal allergic rhinitis, and its safety and efficacy are still being evaluated in clinical trials.
Histamine has one completed Phase 2 clinical trial registered under NCT00537355. This study, titled 'An Evaluation of the Efficacy and Safety of TOLAMBA™ for Ragweed-Allergic Rhinitis in an Environmental Exposure Chamber,' enrolled 271 participants in Canada and evaluated the drug's effects on seasonal allergic rhinitis.
Yes, Histamine is also known as TOLAMBA. In clinical trials, the drug has been referred to by this brand name, as seen in the study title for NCT00537355. Both names refer to the same investigational drug being developed for seasonal allergic rhinitis.