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PIC1

Phase 1

Non-Hodgkin Lymphoma | Monoclonal antibody | Oncology |Precision BioSciences, Inc.|Last Updated: Mar 6, 2026

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
UNCONTROLLEDBiomarker
Total Trials1
Total Enrollment18
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT07456371PIC1 Injection Therapy for Relapsed/Refractory B-NHLPHASE1 RECRUITING 18Mar 1, 2026Feb 1, 2029Mar 6, 20261 China
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Study Endpoints
Primary Endpoints
Incidence of Adverse Events (AEs) after infusion
1 month

Types, frequency and severity of adverse events.

Secondary Endpoints
Overall Response Rate (ORR)
3 months
Best Overall Response (BOR)
3 months
Duration of Response (DOR)
3 months
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Study Design & Arms
AllocationNA
MaskingNONE
ModelSINGLE_GROUP
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
PIC1 InjectionEXPERIMENTAL -
Interventions
NameTypeDescription
PIC1 InjectionBIOLOGICALThree dose groups (1.0×10\^9 TU, 2.0×10\^9 TU, 4.0×10\^9 TU) were set up, starting from the low dose group climbing to explore the safe and effective dose.
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Eligibility Criteria
Age Range18 Years — 75 Years
SexALL
Healthy VolunteersNo
Study Sites1

Inclusion Criteria: * The patient (or their legally authorized representative) has voluntarily agreed to participate in this clinical trial and has signed the Informed Consent Form (ICF), indicating full understanding of the study's objectives and procedures. * Aged 18 to 75 years, regardless of ge...

Countries:China
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Recent Changes (Last 90 Days)
LOWMay 24, 2026NCT07456371studyFirstPostDate: changed