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PIC1

Phase 1

Non-Hodgkin Lymphoma | Monoclonal antibody | Oncology |Precision BioSciences, Inc.|Last Updated: Mar 6, 2026

Target and mechanism

ModalityMonoclonal antibody

Also known as PIC1 Injection

Success Probability

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Market & Valuation

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Trial Design

UNCONTROLLEDBiomarker
Total Trials1
Total Enrollment18

FDA Designations

No designations recorded

Clinical trial landscape

PIC1 · 1 trial · 1 indication

Phase 1 1
NCT07456371PIC1 Injection Therapy for Relapsed/Refractory B-NHLNon-Hodgkin Lymphoma
RECRUITING18 Analytics
PHASE1RECRUITING
PIC1 Injection Therapy for Relapsed/Refractory B-NHL
Non-Hodgkin LymphomaUnlock trial analytics

Study Endpoints

Primary Endpoints

Incidence of Adverse Events (AEs) after infusion
1 month

Types, frequency and severity of adverse events.

Secondary Endpoints

Overall Response Rate (ORR)
3 months
Best Overall Response (BOR)
3 months
Duration of Response (DOR)
3 months
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Study Design & Arms

AllocationNA
MaskingNONE
ModelSINGLE_GROUP
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
PIC1 InjectionEXPERIMENTAL -

Interventions

NameTypeDescription
PIC1 InjectionBIOLOGICALThree dose groups (1.0×10\^9 TU, 2.0×10\^9 TU, 4.0×10\^9 TU) were set up, starting from the low dose group climbing to explore the safe and effective dose.
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Eligibility Criteria

Age Range18 Years to 75 Years
SexALL
Healthy VolunteersNo
Study Sites1

Inclusion Criteria: * The patient (or their legally authorized representative) has voluntarily agreed to participate in this clinical trial and has signed the Informed Consent Form (ICF), indicating full understanding of the study's objectives and procedures. * Aged 18 to 75 years, regardless of ge...

Countries:China
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Frequently asked questions about PIC1

What is PIC1 used for?

PIC1 is an investigational monoclonal antibody being developed for the treatment of Non-Hodgkin Lymphoma. It is currently in Phase 1 clinical development and is not yet approved by regulatory authorities. The drug is being studied in patients with relapsed or refractory B-cell Non-Hodgkin Lymphoma.

Who makes PIC1?

PIC1 is being developed by Precision BioSciences, Inc., a biopharmaceutical company traded on the NASDAQ under the ticker symbol DTIL. The company is conducting a Phase 1 clinical trial of PIC1 in China for the treatment of Non-Hodgkin Lymphoma.

What phase is PIC1 in?

PIC1 is currently in Phase 1 clinical development. It is an investigational drug and has not been approved by the FDA or any other regulatory agency. The ongoing Phase 1 trial is recruiting patients with relapsed or refractory B-cell Non-Hodgkin Lymphoma.

What clinical trials is PIC1 in?

PIC1 is being evaluated in a single Phase 1 clinical trial with the identifier NCT07456371. This trial is titled 'PIC1 Injection Therapy for Relapsed/Refractory B-NHL' and is currently recruiting participants in China. The study is an uncontrolled, open-label trial with an enrollment target of 18 patients.

Is PIC1 the same as PIC1 Injection?

Yes, PIC1 is also known as PIC1 Injection. The drug is administered as an injection and is being studied in a Phase 1 clinical trial for Non-Hodgkin Lymphoma. The alternative name reflects the formulation of the investigational therapy.