Approval Probability
TA Base Rate
Adjusted LOA
ML Risk
Vasopressin · 1 trial · 1 indication
The intraoperative mean pulmonary artery pressure(mPAP) adjusted for systemic mean arterial pressure(MAP), using a time-weighted average mPAP-to-MAP ratio measured during 20 minute period after chest closure
| Arm | Type | Description |
|---|---|---|
| use of vasopressin | ACTIVE_COMPARATOR | Hemodynamic effect of vasopressin on the pulmonary circulation in cardiac surgery patients |
| use of norepinephrine | ACTIVE_COMPARATOR | Hemodynamic effect of norepinephrine on the pulmonary circulation in cardiac surgery patients |
| Name | Type | Description |
|---|---|---|
| Vasopressin | DRUG | Vasopressin (20 IU/100 ml in 5% dextrose) were stored in pre-mixed bags in the operating room, readily available for continuous infusion administration via pre-programed infusion pumps |
| Norepinephrine | DRUG | Norepinephrine (4 mg/250ml in 5% dextrose) were stored in pre-mixed bags in the operating room, readily available for continuous infusion administration via pre-programed infusion pumps |
Inclusion criteria: Adults\> 18 years of age * Elective cardiac surgery with the use of CPB * Patients with pulmonary artery catheter insertion * Systemic hypotension (MAP \< 70 mmHg) requiring continuous infusion of vasopressor Exclusion Criteria: * Transplant surgery * Ventricular assist devic...