Approval Probability
TA Base Rate
Adjusted LOA
ML Risk
Valchlor · 1 trial · 1 indication
Skin erythema (redness) will be quantified using a CR300 chromameter. The difference in erythema between exposed and non-exposed skin will be calculated after valchlor exposure
| Arm | Type | Description |
|---|---|---|
| Group 1: 4 placebo - 0 Vitamin D with Valchlor | PLACEBO_COMPARATOR | Participants will be given 4 placebo capsules and 0 cholecalciferol (Vitamin D) capsules after being treated with Valchlor. |
| Group 2: 0 placebo - 4 Vitamin D with mechloroethamine | EXPERIMENTAL | Participants will be given 0 placebo capsules and 4 cholecalciferol capsules to total 200,000 IU of cholecalciferol (Vitamin D) after being treated with Valchlor. |
| Name | Type | Description |
|---|---|---|
| 4 placebo | DIETARY_SUPPLEMENT | subjects will take orally 4 pills without any active ingredients which are of the same size, shape and color as the study pills |
| 4 Vitamin D | DIETARY_SUPPLEMENT | subjects will take orally four pills for a single dose of 200,000 IU of Vitamin D (cholecalciferol) |
| Valchlor | DRUG | Twice during the study, subjects will be given 0.016% Valchlor at 3 locations (for a total of 6 locations) in the inner arm using Finn ChambersTM |
Inclusion Criteria: * Must be in general good health * Fitzpatrick Skin Type I-VI * Able to list all current medications and medical conditions * Capable of giving informed consent Exclusion Criteria: * Women who are pregnant, nursing, or who may become pregnant in the next 3 months * Participant...