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PIPE-307 Dose A

Phase 2

Relapsing Remitting Multiple Sclerosis | Small molecule | Neurology |Contineum Therapeutics, Inc.|Last Updated: Jul 15, 2026

Target and mechanism

Molecular targetLPAR1
ModalitySmall molecule

Also known as PIPE-791 Dose A

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindPLACEBO_CONTROLLEDDMC
Total Trials1
Total Enrollment182

FDA Designations

No designations recorded

Clinical trial landscape

PIPE-307 Dose A · 1 trial · 1 indication

Phase 2 1
NCT06083753Study to Evaluate the Safety and Efficacy of PIPE-307 in Subjects With Relapsing-Remitting Multiple SclerosisRelapsing Remitting Multiple Sclerosis
COMPLETED182 Analytics
PHASE2COMPLETED
Study to Evaluate the Safety and Efficacy of PIPE-307 in Subjects With Relapsing-Remitting Multiple Sclerosis
Relapsing Remitting Multiple SclerosisUnlock trial analytics

Study Endpoints

Primary Endpoints

Treatment-emergent adverse events (TEAE)
From baseline to week 26 (end of treatment period)

Number of participants with TEAEs

Change in binocular 2.5% low contrast letter acuity (LCLA)
From baseline to week 26 (end-of-study)

Secondary Endpoints

Percentage of subjects with >/=5-letter gain in binocular 2.5% LCLA
From baseline to week 26
Change in monocular 2.5% LCLA
From baseline to week 26
Number of subjects with at least a 15% change in disability with the Timed 25-Foot Walk Test (T25WT)
From baseline to week 26
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Study Design & Arms

AllocationRANDOMIZED
MaskingTRIPLE
ModelPARALLEL
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
PIPE-307 Dose AEXPERIMENTAL -
PIPE-307 Dose BEXPERIMENTAL -
PlaceboPLACEBO_COMPARATOR -

Interventions

NameTypeDescription
PIPE-307 Dose ADRUGSubjects will receive daily oral doses of PIPE-307
PIPE-307 Dose BDRUGSubjects will receive daily oral doses of PIPE-307
PlaceboDRUGSubjects will receive daily oral matching dose of Placebo
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Eligibility Criteria

Age Range18 Years to 50 Years
SexALL
Healthy VolunteersNo
Study Sites21

Inclusion Criteria: * Subject is fluent in English. * Male or female 18 to 50 years of age, inclusive, at the first Screening visit. * A diagnosis of relapsing-remitting multiple sclerosis (RRMS) according to the 2017 Revised McDonald Criteria. * Expanded Disability Status Scale (EDSS) and retinal ...

Countries:United States
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Recent Changes (Last 90 Days)

MEDIUMAug 15, 2026NCT06083753TRIAL_REMOVED: changed
MEDIUMAug 15, 2026NCT06083753TRIAL_REMOVED: changed
MEDIUMAug 15, 2026NCT06083753TRIAL_REMOVED: changed

Frequently asked questions about PIPE-307 Dose A

What is PIPE-791 Dose A used for?

PIPE-791 Dose A is an investigational small molecule being studied for idiopathic pulmonary fibrosis (IPF) and relapsing remitting multiple sclerosis (RRMS). It is currently in Phase 2 clinical development and has not been approved by regulatory authorities.

What does PIPE-791 Dose A target?

PIPE-791 Dose A targets the lysophosphatidic acid receptor 1 (LPAR1). By modulating this receptor, the drug is being evaluated for its potential effects in treating idiopathic pulmonary fibrosis and relapsing remitting multiple sclerosis.

Who makes PIPE-791 Dose A?

PIPE-791 Dose A is being developed by Contineum Therapeutics, Inc., a biopharmaceutical company listed on the NASDAQ under the ticker symbol CTNM.

What phase is PIPE-791 Dose A in?

PIPE-791 Dose A is in Phase 2 clinical development. It is an investigational drug and has not received FDA approval. Clinical trials are ongoing to evaluate its safety and efficacy in patients with idiopathic pulmonary fibrosis.

What clinical trials is PIPE-791 Dose A in?

PIPE-791 Dose A is being studied in a Phase 2 trial (NCT07284459) for idiopathic pulmonary fibrosis, which is currently recruiting 324 participants across multiple countries. A separate Phase 2 trial (NCT06083753) for relapsing remitting multiple sclerosis has been completed.

Is PIPE-791 Dose A the same as PIPE-791?

PIPE-791 Dose A is a specific dose formulation of the investigational drug PIPE-791. The clinical trial NCT07284459 evaluates PIPE-791 in patients with idiopathic pulmonary fibrosis, and the completed trial NCT06083753 studied PIPE-307 in relapsing remitting multiple sclerosis.