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CX-2029

Phase 1

Solid Tumor, Adult | Small molecule | Oncology |CytomX Therapeutics, Inc.|Last Updated: Jan 23, 2024

Success Probability

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Market & Valuation

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Trial Design

CONTROLLEDDMC
Total Trials1
Total Enrollment133

FDA Designations

No designations recorded

Clinical trial landscape

CX-2029 · 1 trial · 5 indications

Phase 1 1
NCT03543813PROCLAIM-CX-2029: A Trial to Find Safe and Active Doses of an Investigational Drug CX-2029 for Patients With Solid Tumors or DLBCLSolid Tumor, Adult
COMPLETED133 Analytics
PHASE1COMPLETED
PROCLAIM-CX-2029: A Trial to Find Safe and Active Doses of an Investigational Drug CX-2029 for Patients With Solid Tumors or DLBCL
Solid Tumor, AdultUnlock trial analytics

Study Endpoints

Primary Endpoints

The number of subjects experiencing a dose-limiting toxicity at various dose levels when given CX-2029 as a monotherapy
21 days (dose-limiting toxicity period)

Secondary Endpoints

The percentage of subjects experiencing anti-cancer activity (ORR) at various dose levels when given CX-2029 as a monotherapy
2 years
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Study Design & Arms

AllocationNON_RANDOMIZED
MaskingNONE
ModelPARALLEL
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
CX-2029 EscalationEXPERIMENTALDose Escalation and Determination
CX-2029 BiomarkerEXPERIMENTALCharacterization of CX-2029 in the tumor microenvironment in subjects with select tumor types
CX-2029 ExpansionEXPERIMENTALEvaluate antitumor activity of CX-2029

Interventions

NameTypeDescription
CX-2029DRUGCX-2029 Monotherapy
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Eligibility Criteria

Age Range18 Years to N/A
SexALL
Healthy VolunteersNo
Study Sites25

Inclusion Criteria: 1. Histologically or cytologically confirmed diagnosis of metastatic or locally advanced unresectable tumors 2. Patients demonstrating disease progression after treatment with approved therapies that are known to confer life-prolonging benefit, or who are intolerant to or have d...

Countries:United StatesSouth KoreaSpainUnited Kingdom
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Frequently asked questions about CX-2029

What is CX-2029 used for?

CX-2029 is an investigational small molecule being studied for the treatment of adult patients with solid tumors, including head and neck cancer, non-small cell lung cancer, and esophageal cancer, as well as diffuse large B cell lymphoma. It is currently in Phase 1 clinical development.

Who makes CX-2029?

CX-2029 is being developed by CytomX Therapeutics, Inc., a biopharmaceutical company traded on the NASDAQ under the ticker symbol CTMX. The company is conducting clinical trials to evaluate the safety and activity of this investigational drug.

What phase is CX-2029 in?

CX-2029 is in Phase 1 clinical development. It is an investigational drug and has not been approved by regulatory authorities. A Phase 1 trial has been completed to evaluate safe and active doses in patients with certain solid tumors or diffuse large B cell lymphoma.

What clinical trials is CX-2029 in?

CX-2029 has been studied in a Phase 1 clinical trial with the identifier NCT03543813, titled PROCLAIM-CX-2029. This completed trial enrolled 133 participants and was conducted in the United States, South Korea, Spain, and the United Kingdom.

Is CX-2029 the same as PROCLAIM-CX-2029?

No, CX-2029 is the investigational drug, while PROCLAIM-CX-2029 is the name of the clinical trial studying it. The trial, identified as NCT03543813, was designed to find safe and active doses of CX-2029 for patients with solid tumors or diffuse large B cell lymphoma.