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Cetrorelix Pamoate

Phase 3

Benign Prostatic Hypertrophy | Small molecule | Nephrology |COSCIENS Biopharma Inc.|Last Updated: Apr 5, 2011

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
UNCONTROLLEDBiomarker
Total Trials1
Total Enrollment528
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00670306Cetrorelix Pamoate IM Regimens in Patients With Symptomatic Benign Prostatic Hyperplasia (BPH)PHASE3 COMPLETED 528Mar 1, 2008Aug 1, 2009Apr 5, 201169 United States, Canada
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Study Endpoints
Primary Endpoints
IPSS Change From Baseline
Baseline and Week 26

International Prostate Symptom Score (IPSS) Patient Questionnaire assessing 7 items (incomplete voiding, frequency, intermittency, urgency, weak stream, hesitancy, nocturia) on a scale from 0 (best) to 5 (worst); total range: 0 - 35 points; absolute change from baseline to Week 26

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Study Design & Arms
AllocationNA
MaskingNONE
ModelSINGLE_GROUP
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
Cetrorelix 78 mgEXPERIMENTALDrug: Cetrorelix 52 mg week 0, and 26 mg week 2, intra muscular-2 doses in 2 weeks and follow up to week 26.
Interventions
NameTypeDescription
Cetrorelix PamoateDRUGCetrorelix Pamoate IM, 52 mg week 0, 26 mg week 2,
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Eligibility Criteria
Age Range50 Years — N/A
SexMALE
Healthy VolunteersNo
Study Sites69

Inclusion Criteria: * Benign Prostatic Hyperplasia, based on medical history * Voiding symptoms * Uroflow (max) 5-15mL/sec Exclusion Criteria: * Urgent need for prostate surgery * History of allergic reaction to peptide * Major organ dysfunction * Prior surgical treatment of the prostate or bladd...

Countries:United StatesCanada
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