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Lactated Ringer's · 1 trial · 1 indication
| Name | Type | Description |
|---|---|---|
| Indomethacin | DRUG | Indomethacin is a non-steroidal anti-inflammatory drug (NSAID) which is commonly used to reduce inflammation caused by gout, osteoarthritis and rheumatoid arthritis. It acts by blocking the cyclo-oxygenase 1 and 2 (COX) receptors. It has also been implicated to prevent post-ERCP pancreatitis |
| Lactated Ringer's Solution | DRUG | Lactated ringer's solution (LR), is an intravenous fluid (IVF) used commonly during endoscopic procedures and operative procedures. It's composition is similar to that of humans including sodium, chloride, potassium, calcium and lactate. Studies have implicated the use of this fluid in pancreatitis treatment and prevention of post-ERCP pancreatitis |
| Normal Saline | DRUG | standard IVF would include 0.9% normal saline (NS) solution used during all endoscopic procedures. 0.9% NS includes equal parts sodium and chloride. |
| Placebo | DRUG | Placebo would be a suppository 50 mg x 2 |
Lactated Ringer's is being studied for the prevention of Post-ERCP Acute Pancreatitis, a complication that can occur after endoscopic retrograde cholangiopancreatography (ERCP). It is an investigational small molecule in Phase 3 clinical development for this indication.
Lactated Ringer's is being developed by The Cooper Companies, Inc. (NYSE: COO). The company is conducting clinical research to evaluate the drug's potential in preventing Post-ERCP Acute Pancreatitis.
Lactated Ringer's is in Phase 3 clinical development for Post-ERCP Acute Pancreatitis. It is an investigational drug and has not been approved for this use. One Phase 3 trial has been completed.
Lactated Ringer's has one completed Phase 3 trial, NCT02641561, titled 'Lactated Ringers With or Without Rectal Indomethacin to Prevent Post-ERCP Pancreatitis.' The trial enrolled 192 participants and was not randomized or double-blinded.
Lactated Ringer's is commonly known as Ringer's lactate solution. It is a balanced crystalloid fluid used in medical settings. In the context of this clinical development, it is being evaluated for preventing Post-ERCP Acute Pancreatitis.