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Chlorhexidine gluconate

Phase 3

Surgical Wound Infection | Small molecule | Infectious Disease |The Cooper Companies, Inc.|Last Updated: Aug 25, 2025

Target and mechanism

ModalitySmall molecule

Also known as Chlorhexidine gluconate (4%)

Success Probability

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Market & Valuation

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Trial Design

UNCONTROLLED
Total Trials1
Total Enrollment848

FDA Designations

No designations recorded

Clinical trial landscape

Chlorhexidine gluconate · 1 trial · 1 indication

Phase 3 1
NCT07142408The Effect of Bacterial Decolonization Before Skin Cancer Surgery on Infection Rate of Lower Extremity Wounds Left Open to HealSurgical Wound Infection
RECRUITING848 Analytics
PHASE3RECRUITING
The Effect of Bacterial Decolonization Before Skin Cancer Surgery on Infection Rate of Lower Extremity Wounds Left Open to Heal
Surgical Wound InfectionUnlock trial analytics

Study Design & Arms

Interventions

NameTypeDescription
Chlorhexidine gluconate (4%)DRUGChlorhexidine 4% solution will be applied from the neck down (avoiding the face, penis, and vagina), allowed to sit on the skin for one minute, then rinsed off in the shower every day for 5 days prior to surgery.
Mupirocin 2% OintmentDRUGMupirocin 2% ointment will be applied to the inside of the nostrils twice daily, in the morning and evening, for 5 days prior to surgery. A small amount of the ointment will be placed on the tip of a cotton swab to facilitate application to each nostril.
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Frequently asked questions about Chlorhexidine gluconate

What is Chlorhexidine gluconate used for?

Chlorhexidine gluconate is being studied for the prevention of surgical wound infection, specifically in patients undergoing skin cancer surgery on the lower extremities. It is an investigational small molecule in Phase 3 clinical development for this indication.

Who makes Chlorhexidine gluconate?

Chlorhexidine gluconate is being developed by The Cooper Companies, Inc., a company traded on the New York Stock Exchange under the ticker COO. The company is conducting a Phase 3 clinical trial to evaluate the drug for surgical wound infection prevention.

What phase is Chlorhexidine gluconate in?

Chlorhexidine gluconate is in Phase 3 clinical development. It is an investigational drug and has not been approved by regulatory authorities. The ongoing Phase 3 trial is currently recruiting participants to study its effect on infection rates in lower extremity wounds.

What clinical trials is Chlorhexidine gluconate in?

Chlorhexidine gluconate is being evaluated in a Phase 3 clinical trial with the identifier NCT07142408. This trial is studying the effect of bacterial decolonization before skin cancer surgery on infection rates of lower extremity wounds left open to heal. The trial is currently recruiting and aims to enroll 848 participants.

Is Chlorhexidine gluconate the same as Chlorhexidine gluconate (4%)?

Yes, Chlorhexidine gluconate is also known as Chlorhexidine gluconate (4%). The 4% formulation is the specific concentration being studied in the Phase 3 clinical trial for surgical wound infection prevention.