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HLD100

Phase 2

Attention-Deficit Hyperactivity Disorder (ADHD) | Small molecule | Psychiatry |Collegium Pharmaceutical, Inc.|Last Updated: Jul 19, 2021

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
CONTROLLEDDMCBiomarker
Total Trials1
Total Enrollment22
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT02884544A Study of Delayed and Extended Release Formulation of Dextroamphetamine Sulfate (HLD100) in Children With ADHDPHASE2 COMPLETED 22Aug 1, 2016Dec 27, 2016Jul 19, 20211 United States
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Study Endpoints
Primary Endpoints
Dose Escalation to determine optimal dosage for clinical effects
6 weeks

Primary outcome is the determination of the dose achieving optimal clinical effect in a safe and tolerable manner

Secondary Endpoints
Safety (AEs, ECG, laboratory parameters, physical examinations)
48 hours
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Study Design & Arms
AllocationNON_RANDOMIZED
MaskingNONE
ModelSEQUENTIAL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
HLD100 10mgEXPERIMENTALHLD100 (dextroamphetamine sulfate) DR/ER capsules (10mg)
HLD100 20mgEXPERIMENTALHLD100 (dextroamphetamine sulfate) DR/ER capsules (20mg)
HLD100 30mgEXPERIMENTALHLD100 (dextroamphetamine sulfate) DR/ER capsules (30mg)
HLD100 40mgEXPERIMENTALHLD100 (dextroamphetamine sulfate) DR/ER capsules (40mg)
Interventions
NameTypeDescription
HLD100DRUGTreatment
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Eligibility Criteria
Age Range6 Years — 12 Years
SexALL
Healthy VolunteersNo
Study Sites1

Inclusion Criteria: * Subjects must have a diagnosis of ADHD as defined by DSM-5 criteria with confirmation using the Mini International Neuropsychiatric Interview for Children and Adolescents (MINI-KID). * Subjects must demonstrate mild-to-moderate impairment of ADHD symptoms and function per the ...

Countries:United States
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