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BEMA Fentanyl

Phase 3

Respiratory Depression | Small molecule | Psychiatry |Collegium Pharmaceutical, Inc.|Last Updated: Sep 24, 2019

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
UNCONTROLLED
Total Trials1
Total Enrollment5
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00696137Long-term Extension Study of BEMA™ FentanylPHASE3 COMPLETED 5Jun 1, 2008Jul 1, 2009Sep 24, 2019 -
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Study Endpoints
Primary Endpoints
Efficacy Was Not Measured in This Study. The Number of Deaths in the Long Term Follow-up Will be Reported.
3 years

Efficacy was not measured in this study as the intention was to evaluate long term safety in this population. The number of deaths in the long term follow-up will be reported.

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Study Design & Arms
AllocationNA
MaskingNONE
ModelSINGLE_GROUP
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
BEMA FentanylEXPERIMENTALBEMA Fentanyl
Interventions
NameTypeDescription
BEMA FentanylDRUGbuccal soluble film; 200, 400, 600, 800, and 1200 mcg fentanyl; up to 4 times daily
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Eligibility Criteria
Age Range18 Years — N/A
SexALL
Healthy VolunteersNo

Inclusion Criteria: 1. previously qualified for and participated in study FEN-202 for at least 2 weeks, 2. wish to continue using BEMA Fentanyl for treatment of breakthrough pain episodes, and 3. provide signed informed consent at screening prior to any study procedures. Exclusion Criteria: 1. th...

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