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BEMA Buprenorphine NX films

Phase 2

Opioid Dependence | Small molecule | Pain |Collegium Pharmaceutical, Inc.|Last Updated: Apr 4, 2017

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
UNCONTROLLEDBiomarker
Total Trials1
Total Enrollment249
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT01666119An Open Label Study To Assess The Safety And Tolerability Of BEMA® Buprenorphine NX In Opioid Dependent SubjectsPHASE2 COMPLETED 249Aug 1, 2012Jan 1, 2013Apr 4, 201710 United States
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Study Endpoints
Primary Endpoints
Adverse Events
12 weeks

Adverse events that occur in more than 2 subjects. Among the adverse events that occurred in \> 2 subjects, the total number of unique events that were experienced are reported.

Secondary Endpoints
Urine Drug Screen
12 weeks
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Study Design & Arms
AllocationNA
MaskingNONE
ModelSINGLE_GROUP
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
BEMA Buprenorphine NX filmsEXPERIMENTALBEMA Buprenorphine NX films (3.5/0.6 mg and 5.25/0.9 mg buprenorphine/naloxone)will be provided in 3.361 and 5.447 cm2 film sizes, respectively.
Interventions
NameTypeDescription
BEMA Buprenorphine NX filmsDRUGBEMA Buprenorphine NX films (3.5/0.6 mg and 5.25/0.9 mg buprenorphine/naloxone) will be provided in 3.361 and 5.447 cm2 film sizes, respectively.
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Eligibility Criteria
Age Range18 Years — 65 Years
SexALL
Healthy VolunteersNo
Study Sites10

Inclusion Criteria: 1. Written informed consent obtained at Screening, prior to any study procedure being performed 2. Male or non-pregnant and non-nursing female. A female of childbearing potential is eligible to participate in this study if she is not pregnant, and is using an acceptable method o...

Countries:United States
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