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MK-1406

Phase 2

Healthy Participants | Small molecule | Other |Cidara Therapeutics, Inc.|Last Updated: Aug 20, 2026

Target and mechanism

ModalitySmall molecule

Also known as MK-1406 Injection

Success Probability

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Market & Valuation

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Trial Design

UNCONTROLLED
Total Trials1
Total Enrollment400

FDA Designations

No designations recorded

Clinical trial landscape

MK-1406 · 1 trial · 1 indication

Phase 2 1
NCT07225959A Study of Annual Doses of MK-1406/CD388 in Healthy Adults (MK-1406-006/CD388.SQ.2.07)Healthy Participants
ACTIVE NOT_RECRUITING400 Analytics
PHASE2ACTIVE NOT_RECRUITING
A Study of Annual Doses of MK-1406/CD388 in Healthy Adults (MK-1406-006/CD388.SQ.2.07)
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Study Endpoints

Primary Endpoints

Number of Participants with Treatment-Induced Anti-Drug Antibodies (ADAs)
Periods 1 and 2: Day 1, Day 29, Day 85, Day 169, and Day 197

Participants are evaluated for the occurrence of treatment-induced ADAs following administration of each annual dose of MK-1406.

Number of Participants with Treatment-Boosted ADAs
Periods 1 and 2: Day 1, Day 29, Day 85, Day 169, and Day 197

Participants are evaluated for the occurrence of treatment-boosted ADAs following administration of each annual dose of MK-1406.

Secondary Endpoints

Number of participants with ≥1 Adverse Event (AE)
Period 1: Up to approximately Day 280. Period 2: Up to approximately Day 197.
Number of Participants Who Discontinued from the Study Due to an AE
Period 1: Up to approximately Day 280. Period 2: Up to approximately Day 197.
Number of Participants with a Solicited Injection-site AE
Up to approximately Day 8 post dose
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Study Design & Arms

AllocationNA
MaskingNONE
ModelSINGLE_GROUP
PurposePREVENTION

Treatment Arms

ArmTypeDescription
MK-1406EXPERIMENTALParticipant will receive 450 mg dose of MK-1406 (CD388) by subcutaneous (SC) injection followed 1 year later by a repeat single 450 mg dose of MK-1406 administered by SC injection.

Interventions

NameTypeDescription
MK-1406 InjectionCOMBINATION_PRODUCTMK-1406 liquid for injection administered subcutaneously
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Eligibility Criteria

Age Range18 Years to 66 Years
SexALL
Healthy VolunteersYes
Study Sites6

Inclusion Criteria: The main inclusion criteria include but are not limited to the following: * Be in stable health * Has previously completed participation in study CD388.SQ.2.05/MK-1406-004, and received a subcutaneous (SC) CD388/MK-1406 dose of either 150 mg, 300 mg or 450 mg. Exclusion Criter...

Countries:United StatesUnited Kingdom
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Recent Changes (Last 90 Days)

MEDIUMAug 20, 2026NCT07225959primaryCompletionDate: changed
MEDIUMAug 20, 2026NCT07225959primaryCompletionDate: changed

Frequently asked questions about MK-1406

What is MK-1406 used for?

MK-1406 is an investigational small molecule being studied in healthy participants. It is currently in Phase 2 clinical development, with an active trial evaluating annual doses of MK-1406 in healthy adults. The drug is not approved and remains under investigation.

Who makes MK-1406?

MK-1406 is being developed by Cidara Therapeutics, Inc., a biopharmaceutical company traded on the NASDAQ under the ticker symbol CDTX. The company is conducting clinical trials to evaluate the safety and tolerability of this investigational drug.

What phase is MK-1406 in?

MK-1406 is in Phase 2 clinical development. It is an investigational drug, meaning it has not been approved by regulatory authorities. The current Phase 2 trial is active but not recruiting participants, and the drug remains under clinical investigation.

What clinical trials is MK-1406 in?

MK-1406 is being studied in one active Phase 2 clinical trial with the identifier NCT07225959. This trial, titled 'A Study of Annual Doses of MK-1406/CD388 in Healthy Adults,' is enrolling 400 healthy participants across the United States and United Kingdom.

Is MK-1406 the same as MK-1406 Injection?

Yes, MK-1406 is also known as MK-1406 Injection. The drug is administered as an injection, and both names refer to the same investigational product being developed by Cidara Therapeutics for use in healthy participants.