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Polidocanol Endovenous Microfoam

Phase 1

Varicose Veins | Small molecule | Other |Boston Scientific Corporation|Last Updated: Apr 21, 2021

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedCONTROLLEDBiomarker
Total Trials1
Total Enrollment21
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT01428076Pharmacokinetic Study of Polidocanol Endovenous Microfoam (PEM)PHASE1 COMPLETED 21Aug 1, 2011Jan 1, 2012Apr 21, 20211 United States
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Study Endpoints
Primary Endpoints
Weight-adjusted Polidocanol Cmax (Serum)
pharmacokinetics measured- predose, 1, 4, 5, 7, 9, 11, 14, 15, 17, 20, 25, 30 minutes post dose, 1, 2, 3, 4, 5, 6, 8 hours post dose

Cmax measured and adjusted for weight

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Study Design & Arms
AllocationRANDOMIZED
MaskingNONE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
High Dose Polidocanol Endovenous MicrofoamEXPERIMENTAL -
Medium Dose Polidocanol Endovenous MicrofoamEXPERIMENTAL -
Interventions
NameTypeDescription
Polidocanol Endovenous Microfoam (PEM)DRUGPharmacokinetic comparison of different doses of drug
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Eligibility Criteria
Age Range18 Years — 75 Years
SexALL
Healthy VolunteersNo
Study Sites1

Inclusion Criteria: * Male or female; age 18 to 75 years * Superficial venous disease where SFJ incompetence is the predominant source of reflux (reflux \> 0.5 seconds on duplex ultrasonography) associated with incompetence of the great saphenous vein (GSV) or other major accessory vein * Expected ...

Countries:United States
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