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valacyclovir

Phase 2

Herpes Zoster | Small molecule | Infectious Disease |Bristol-Myers Squibb Company|Last Updated: Oct 12, 2015

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindACTIVE_CONTROLLEDBiomarker
Total Trials1
Total Enrollment350
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00900783A Study of FV-100 Versus Valacyclovir in Patients With Herpes ZosterPHASE2 COMPLETED 350May 1, 2009Dec 1, 2010Oct 12, 2015 -
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Study Endpoints
Primary Endpoints
Herpes zoster associated pain, as measured by the Zoster Brief Pain INventory (ZBPI)
30 days
Secondary Endpoints
Herpes zoster associated pain
90 days
Herpes zoster lesion healing
Until healed
Routine clinical labs
30 days
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Study Design & Arms
AllocationRANDOMIZED
MaskingQUADRUPLE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
2EXPERIMENTALFV-100, 400 mg once daily AND valacyclovir placebo, three times a day, for seven days
3ACTIVE_COMPARATORValacyclovir, 1 gram, three times a day AND FV-100 placebo, once daily, for seven days
1EXPERIMENTALFV-100, 200 mg once daily AND valacyclovir placebo, three times a day, for seven days
Interventions
NameTypeDescription
valacyclovirDRUG1 gram, three times a day for seven days
FV-100DRUG400 mg, once daily, for seven days
Valacyclovir placeboDRUGthree times a day, for seven days
FV-100 placeboDRUGonce daily, for seven days
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Eligibility Criteria
Age Range50 Years — N/A
SexALL
Healthy VolunteersNo

Inclusion Criteria: * Men and women ≥ 50 years of age * Patients with a clinical diagnosis of HZ as evidenced by a unilateral dermatomal rash * Patients with zoster-related pain (ZBPI worst pain score \> 0) * Patients able to be enrolled into the study ≤ 72 hours from appearance of rash (i.e., lesi...

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