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RYZ801

Phase 1

HCC | Small molecule | Oncology |Bristol-Myers Squibb Company|Last Updated: May 24, 2025

Target and mechanism

Molecular targetBCMA
Target classProtein
ModalitySmall molecule

Success Probability

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Market & Valuation

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Trial Design

UNCONTROLLED
Total Trials1
Total Enrollment70

FDA Designations

No designations recorded

Clinical trial landscape

RYZ801 · 1 trial · 1 indication

Phase 1 1
NCT06726161Study of the Theranostic Pair RYZ811 (Diagnostic) and RYZ801 (Therapeutic) to Identify and Treat Subjects With GPC3+ Unresectable HCCHCC
RECRUITING70 Analytics
PHASE1RECRUITING
Study of the Theranostic Pair RYZ811 (Diagnostic) and RYZ801 (Therapeutic) to Identify and Treat Subjects With GPC3+ Unresectable HCC
HCCUnlock trial analytics

Study Design & Arms

Interventions

NameTypeDescription
RYZ811DIAGNOSTIC_TESTGa-68
RYZ801DRUGAc-225
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Frequently asked questions about RYZ801

What is RYZ801 used for in HCC?

RYZ801 is an investigational small molecule being studied for the treatment of hepatocellular carcinoma (HCC), specifically in subjects with GPC3+ unresectable HCC. It is being evaluated as part of a theranostic pair with RYZ811, a diagnostic agent, to identify and treat patients with this condition.

What does RYZ801 target?

RYZ801 targets BCMA, a protein. It is being studied in combination with the diagnostic RYZ811 to identify and treat subjects with GPC3+ unresectable hepatocellular carcinoma (HCC). The therapeutic agent is designed to work alongside the diagnostic to target the disease.

Who makes RYZ801?

RYZ801 is being developed by Bristol-Myers Squibb Company (ticker: BMY). The company is conducting a Phase 1 clinical trial to evaluate the drug in patients with hepatocellular carcinoma (HCC).

What phase is RYZ801 in?

RYZ801 is in Phase 1 clinical development. It is an investigational drug and has not been approved by the FDA. The ongoing trial is recruiting participants to study the theranostic pair RYZ811 and RYZ801 in subjects with GPC3+ unresectable HCC.

What clinical trials is RYZ801 in?

RYZ801 is being studied in a Phase 1 clinical trial with the identifier NCT06726161. The trial is titled 'Study of the Theranostic Pair RYZ811 (Diagnostic) and RYZ801 (Therapeutic) to Identify and Treat Subjects With GPC3+ Unresectable HCC' and is currently recruiting 70 participants.

Is RYZ801 the same as RYZ811?

No, RYZ801 and RYZ811 are different agents. RYZ801 is the therapeutic drug, while RYZ811 is the diagnostic agent. They are studied together as a theranostic pair to identify and treat subjects with GPC3+ unresectable hepatocellular carcinoma (HCC).