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RYZ401

Phase 1

GEP-NET | Small molecule | Oncology |Bristol-Myers Squibb Company|Last Updated: Sep 9, 2025

Target and mechanism

Molecular targetPRMT5
Target classProtein
ModalitySmall molecule

Success Probability

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Market & Valuation

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Trial Design

UNCONTROLLED
Total Trials1
Total Enrollment104

FDA Designations

No designations recorded

Clinical trial landscape

RYZ401 · 1 trial · 9 indications

Phase 1 1
NCT07165132Study of RYZ401 in Subjects With Solid Tumors Expressing SSTRs.GEP-NET
NOT YET_RECRUITING104 Analytics
PHASE1NOT YET_RECRUITING
Study of RYZ401 in Subjects With Solid Tumors Expressing SSTRs.
GEP-NETUnlock trial analytics

Study Design & Arms

Interventions

NameTypeDescription
RYZ401DRUGAc-225
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Frequently asked questions about RYZ401

What is RYZ401 used for?

RYZ401 is an investigational small molecule being developed for the treatment of gastroenteropancreatic neuroendocrine tumors (GEP-NET), a type of solid tumor that expresses somatostatin receptors. It is currently in Phase 1 clinical development and has not been approved by the FDA.

What does RYZ401 target?

RYZ401 targets PRMT5, a protein that plays a role in cellular processes. By targeting PRMT5, RYZ401 is being studied for its potential effects in treating gastroenteropancreatic neuroendocrine tumors (GEP-NET) and other solid tumors that express somatostatin receptors.

Who makes RYZ401?

RYZ401 is being developed by Bristol-Myers Squibb Company, which trades under the ticker symbol BMY. The company is currently conducting clinical trials to evaluate the safety and efficacy of RYZ401 in patients with solid tumors expressing somatostatin receptors.

What phase is RYZ401 in?

RYZ401 is in Phase 1 clinical development. It is an investigational drug, meaning it has not yet been approved by regulatory authorities. The ongoing Phase 1 trial is designed to study the drug in subjects with solid tumors that express somatostatin receptors.

What clinical trials is RYZ401 in?

RYZ401 is being studied in a Phase 1 clinical trial with the identifier NCT07165132. The trial, titled 'Study of RYZ401 in Subjects With Solid Tumors Expressing SSTRs,' is not yet recruiting and aims to enroll 104 participants with conditions including GEP-NET and other neuroendocrine tumors.