Approval Probability
TA Base Rate
Adjusted LOA
ML Risk
Pentaspan · 1 trial · 1 indication
| Arm | Type | Description |
|---|---|---|
| 1 colloid | ACTIVE_COMPARATOR | Boluses of fluids are a pentastarch (up to 1000 ml) |
| 2. Crytalloid | ACTIVE_COMPARATOR | Boluses are given as normal saline |
| Name | Type | Description |
|---|---|---|
| Pentaspan | OTHER | When fluids are indicated either pentaspan or saline are given in a double blind randomized assignment |
Inclusion Criteria: * status post cardiac surgery * pulmonary artery occlusion catheter in place * informed consent * morning case (must be out of OR by 2:00 PM Exclusion Criteria: * excessive bleeding (\> 200 cc/hr) * intraaortic balloon pump * refusal by treating team * emergency cases * patien...
Pentaspan is an investigational drug being studied for use in cardiac surgery. It is being evaluated as a resuscitation fluid after cardiac surgery, as part of a double-blind randomized trial comparing it to saline. The drug is in Phase 2 clinical development for this indication.
Pentaspan is being developed by Bristol-Myers Squibb Company, which trades under the ticker symbol BMY. The company is conducting clinical research on this drug for use in cardiac surgery, with the drug currently in Phase 2 development.
Pentaspan is in Phase 2 clinical development. It is an investigational drug, meaning it has not been approved by regulatory authorities and is still being studied in clinical trials. The drug is being evaluated for use in cardiac surgery, specifically for resuscitation after the procedure.
Pentaspan has one completed clinical trial registered under NCT00337805, titled "Double Blind Randomized Trial of Saline vs Pentaspan for Resuscitation After Cardiac Surgery." This Phase 2 trial enrolled 240 participants in Canada and was a randomized, double-blind, active-controlled study.
No, Pentaspan is not the same as saline. In the clinical trial NCT00337805, Pentaspan was compared directly against saline for resuscitation after cardiac surgery. The trial was designed to evaluate the effects of Pentaspan relative to the saline control in this patient population.