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MDX-1401

Phase 1

Hodgkin's Lymphomas | Monoclonal antibody | Oncology |Bristol-Myers Squibb Company|Last Updated: Dec 6, 2012

Success Probability

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Market & Valuation

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Trial Design

UNCONTROLLED
Total Trials1
Total Enrollment22

FDA Designations

No designations recorded

Clinical trial landscape

MDX-1401 · 1 trial · 1 indication

Phase 1 1
NCT00634452Phase 1 Study of MDX-1401 in Patients With CD30-positive Refractory/Relapsed Hodgkin's LymphomaHodgkin's Lymphomas
COMPLETED22 Analytics
PHASE1COMPLETED
Phase 1 Study of MDX-1401 in Patients With CD30-positive Refractory/Relapsed Hodgkin's Lymphoma
Hodgkin's LymphomasUnlock trial analytics

Study Endpoints

Primary Endpoints

Safety and Tolerability Profile
Two years

Secondary Endpoints

Objective Response Rate (ORR)
Day 50
Tumor response assessment
Two year
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Study Design & Arms

AllocationNA
MaskingNONE
ModelSINGLE_GROUP
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
MDX-1401EXPERIMENTALMDX-1401 iv at various doses

Interventions

NameTypeDescription
MDX-1401BIOLOGICALIV weekly for 4 weeks
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Eligibility Criteria

Age Range12 Years to N/A
SexALL
Healthy VolunteersNo
Study Sites6

Inclusion Criteria: * Diagnosis of CD30-positive HL by immunohistochemistry or flow cytometry * Must have failed or relapsed following second line chemotherapy or radiation or failed/relapsed following autologous stem cell transplant * Bi-measurable disease * ECOG Performance Status of 0 - 2 * Meet...

Countries:United States
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Frequently asked questions about MDX-1401

What is MDX-1401 used for?

MDX-1401 is an investigational monoclonal antibody being studied for the treatment of Hodgkin's Lymphomas. It is being developed by Bristol-Myers Squibb Company (BMY) and is currently in Phase 1 clinical development.

What does MDX-1401 target?

MDX-1401 targets CD30, a protein expressed on the surface of certain cancer cells. It is being studied in patients with CD30-positive refractory or relapsed Hodgkin's Lymphoma.

Who makes MDX-1401?

MDX-1401 is being developed by Bristol-Myers Squibb Company, which trades under the ticker symbol BMY on the stock market.

What phase is MDX-1401 in?

MDX-1401 is in Phase 1 clinical development. It is an investigational drug and has not been approved by regulatory authorities. A Phase 1 study has been completed.

What clinical trials is MDX-1401 in?

MDX-1401 has been studied in a Phase 1 clinical trial with the identifier NCT00634452. This trial enrolled 22 patients with CD30-positive refractory or relapsed Hodgkin's Lymphoma and has been completed.

Is MDX-1401 the same as any other drug?

MDX-1401 is a distinct investigational monoclonal antibody developed by Bristol-Myers Squibb. No alternative names for this drug have been disclosed.