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EVRI

Phase 1

Cancer | Small molecule | Oncology |Bristol-Myers Squibb Company|Last Updated: Jul 31, 2008

Success Probability

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Market & Valuation

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Trial Design

UNCONTROLLED
Total Trials1
Total Enrollment17

FDA Designations

No designations recorded

Clinical trial landscape

EVRI · 1 trial · 1 indication

Phase 1 1
NCT00578916Pharmacokinetics and Metabolism of Radiolabeled BMS-690514 in Healthy Male SubjectsCancer
COMPLETED17 Analytics
PHASE1COMPLETED
Pharmacokinetics and Metabolism of Radiolabeled BMS-690514 in Healthy Male Subjects
CancerUnlock trial analytics

Study Endpoints

Primary Endpoints

Single dose pharmacokinetics of BMS-690514 and radioactivity in plasma and urine
measured for 10 days post-dose

Secondary Endpoints

Determination of biotransformation profiles and recorded adverse events
for 10 days post-dose
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Study Design & Arms

AllocationNON_RANDOMIZED
MaskingNONE
ModelSINGLE_GROUP
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
1EXPERIMENTAL -

Interventions

NameTypeDescription
EVRI (BMS-690514)DRUGOral Solution, Oral, 200 mg, single dose followed by 10-12 day inpatient stay
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Eligibility Criteria

Age Range18 Years to 45 Years
SexMALE
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * Healthy male subjects * Body mass index (BMS) of 18 - 30 kg/m², inclusive Exclusion Criteria: * Radiation exposure from diagnostic X-rays (except dental X-rays) in the last year or from clinical trials in the last 5 years

Countries:Switzerland
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Frequently asked questions about EVRI

What is EVRI?

EVRI is an investigational small molecule being developed by Bristol-Myers Squibb Company (BMY) for the treatment of cancer. It is currently in Phase 1 clinical development, meaning it has not yet been approved by regulatory authorities and remains under study to evaluate its safety and pharmacokinetics.

What is EVRI used for in cancer?

EVRI is being studied for use in cancer. It is an investigational oncology small molecule, and its clinical development program includes a Phase 1 trial focused on evaluating the pharmacokinetics and metabolism of the drug in healthy subjects, which is a step toward understanding how it may be used in cancer treatment.

Who makes EVRI?

EVRI is being developed by Bristol-Myers Squibb Company, a biopharmaceutical company listed on the stock exchange under the ticker symbol BMY. The company is conducting clinical research on this investigational oncology small molecule.

What phase is EVRI in?

EVRI is in Phase 1 clinical development. It is an investigational drug, not yet approved, and is being studied in early-stage trials to assess its pharmacokinetics and metabolism. The single completed Phase 1 trial enrolled 17 participants.

What clinical trials is EVRI in?

EVRI has one completed Phase 1 clinical trial, identified as NCT00578916, titled "Pharmacokinetics and Metabolism of Radiolabeled BMS-690514 in Healthy Male Subjects." This uncontrolled, non-randomized study enrolled 17 healthy male volunteers in Switzerland and was not biomarker-selected.