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CC-90006

Phase 1

Psoriasis | Small molecule | Immunology |Bristol-Myers Squibb Company|Last Updated: May 7, 2020

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindPLACEBO_CONTROLLEDBiomarker
Total Trials1
Total Enrollment34
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT03337022Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of CC-90006 in Subjects With Mild to Moderate Plaque-type PsoriasisPHASE1 COMPLETED 34Jan 4, 2018Apr 26, 2019May 7, 20204 United States, Canada
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Study Endpoints
Primary Endpoints
Adverse Events (AEs)
Up to approximately Week 20

Number of participants with adverse events

Secondary Endpoints
Pharmacokinetics: Cmax
Up to approximately 16 weeks
Pharmacokinetics - Tmax
Up to approximately 16 weeks
Pharmacokinetics - AUC 0-t
Up to approximately 16 weeks
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Study Design & Arms
AllocationRANDOMIZED
MaskingQUADRUPLE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
CC-90006; Dose level 1EXPERIMENTALCC-90006 will be administered subcutaneously (SC) on days 1, 15, and 29.
CC-90006; Dose level 2EXPERIMENTALCC-90006 will be administered subcutaneously (SC) on days 1, 15, and 29.
CC-90006; Dose level 3EXPERIMENTALCC-90006 will be administered subcutaneously (SC) on days 1, 15, and 29.
CC-90006; Dose level 4EXPERIMENTALCC-90006 will be administered subcutaneously (SC) on days 1, 15, and 29.
PlaceboPLACEBO_COMPARATORPlacebo (saline) will be administered subcutaneously (SC) on days 1, 15, and 29.
Interventions
NameTypeDescription
CC-90006DRUGCC-90006
PlaceboOTHERPlacebo
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Eligibility Criteria
Age Range18 Years — 60 Years
SexALL
Healthy VolunteersNo
Study Sites4

Inclusion Criteria: The following is a summary of the inclusion criteria: 1. Males or non-pregnant females between the ages of 18 and 60 years (inclusive) at the time of signing the ICF, and be willing to adhere to the requirements of contraception use throughout the study. 1. Female subjects ...

Countries:United StatesCanada
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