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BMS-986470

Phase 1

Anemia, Sickle Cell | Small molecule | Hematology |Bristol-Myers Squibb Company|Last Updated: Mar 17, 2026

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindCONTROLLEDBiomarker
Total Trials1
Total Enrollment184
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT06481306A Study to Evaluate BMS-986470 in Healthy Volunteers and Participants With Sickle Cell DiseasePHASE1 RECRUITING 184 — — Jul 17, 2024Nov 16, 2027Mar 17, 202619 United States, France +1
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Study Endpoints
Primary Endpoints
Number of participants with adverse events (AEs)
Up to 26 months
Number of participants with serious adverse events (SAEs)
Up to 26 months
Number of participants with AEs meeting protocol-defined Dose Limiting Toxicity (DLT) criteria
Up to 26 months
Number of participants with AEs leading to discontinuation
Up to 26 months
Number of deaths
Up to 26 months
Secondary Endpoints
Maximum observed plasma concentration (Cmax)
Up to Day 28
Area under the concentration-time curve (AUC)
Up to Day 28
Time of maximum observed plasma concentration (Tmax)
Up to Day 28
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Study Design & Arms
AllocationRANDOMIZED
MaskingQUADRUPLE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
Cohort A Part 1EXPERIMENTAL -
Cohort A Part 2EXPERIMENTAL -
Cohort A Part 3EXPERIMENTAL -
Cohort B Part 1EXPERIMENTAL -
Cohort B Part 2EXPERIMENTAL -
Interventions
NameTypeDescription
BMS-986470DRUGSpecified dose on specified days
PlaceboDRUGSpecified dose on specified days
FamotidineDRUGSpecified dose on specified days
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Eligibility Criteria
Age Range18 Years — N/A
SexALL
Healthy VolunteersYes
Study Sites19

Inclusion Criteria \- Cohort A. i) Healthy male and female (who are not of childbearing potential) participants, as determined by the investigator based on medical history and other determinations. Females not of childbearing potential must have been amenorrhoeic for at least 12 months without an ...

Countries:United StatesFranceUnited Kingdom
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Recent Changes (Last 90 Days)
LOWMay 26, 2026NCT06481306primaryCompletionDate: changed
LOWMay 24, 2026NCT06481306studyFirstPostDate: changed