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BMS-986470

Phase 1

Anemia, Sickle Cell | Small molecule | Hematology |Bristol-Myers Squibb Company|Last Updated: Aug 18, 2026

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindCONTROLLED
Total Trials1
Total Enrollment224

FDA Designations

No designations recorded

Clinical trial landscape

BMS-986470 · 1 trial · 2 indications

Phase 1 1
NCT06481306A Study to Evaluate BMS-986470 in Healthy Volunteers and Participants With Sickle Cell DiseaseAnemia, Sickle Cell
RECRUITING224 Analytics
PHASE1RECRUITING
A Study to Evaluate BMS-986470 in Healthy Volunteers and Participants With Sickle Cell Disease
Anemia, Sickle CellUnlock trial analytics

Study Endpoints

Primary Endpoints

Number of participants with adverse events (AEs)
Up to 26 months
Number of participants with serious adverse events (SAEs)
Up to 26 months
Number of participants with AEs meeting protocol-defined Dose Limiting Toxicity (DLT) criteria
Up to 26 months
Number of participants with AEs leading to discontinuation
Up to 26 months
Number of deaths
Up to 26 months
Proportion of participants achieving HbF ≥ 10%
Up to 28 days after last dose
Proportion of participants achieving HbF ≥ 20%
Up to 28 days after last dose
Proportion of participants achieving HbF ≥ 30%
Up to 28 days after last dose

Secondary Endpoints

Maximum observed plasma concentration (Cmax)
Up to Day 28
Area under the concentration-time curve (AUC)
Up to Day 28
Time of maximum observed plasma concentration (Tmax)
Up to Day 28
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Study Design & Arms

AllocationRANDOMIZED
MaskingQUADRUPLE
ModelPARALLEL
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
Cohort A Part 1EXPERIMENTAL -
Cohort A Part 2EXPERIMENTAL -
Cohort A Part 3EXPERIMENTAL -
Cohort B Part 1EXPERIMENTAL -
Cohort B Part 2EXPERIMENTAL -

Interventions

NameTypeDescription
BMS-986470DRUGSpecified dose on specified days
PlaceboDRUGSpecified dose on specified days
FamotidineDRUGSpecified dose on specified days
PantoprazoleDRUGSpecified dose on specified days
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Eligibility Criteria

Age Range18 Years to N/A
SexALL
Healthy VolunteersYes
Study Sites32

Inclusion Criteria: Cohort A: * Healthy male and female (who are not of childbearing potential) participants, as determined by the investigator based on medical history and other determinations. Females not of childbearing potential must have been amenorrhoeic for at least 12 months without an alt...

Countries:United StatesCanadaFranceItalyUnited Kingdom
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Recent Changes (Last 90 Days)

LOWAug 19, 2026NCT06481306primaryCompletionDate: changed
LOWAug 19, 2026NCT06481306primaryCompletionDate: changed
LOWAug 19, 2026NCT06481306primaryCompletionDate: changed
MEDIUMJul 6, 2026NCT06481306Enrollment: 184 → 224
MEDIUMJul 6, 2026NCT06481306Enrollment: 184 → 224
LOWJun 16, 2026NCT06481306lastUpdatePostDate: changed
LOWJun 16, 2026NCT06481306lastUpdatePostDate: changed
LOWJun 16, 2026NCT06481306lastUpdatePostDate: changed

Frequently asked questions about BMS-986470

What is BMS-986470 used for?

BMS-986470 is an investigational small molecule being developed for the treatment of anemia and sickle cell disease. It is currently in Phase 1 clinical development, with a study evaluating its effects in healthy volunteers and participants with sickle cell disease.

Who makes BMS-986470?

BMS-986470 is being developed by Bristol-Myers Squibb Company, which trades on the New York Stock Exchange under the ticker symbol BMY. The company is conducting a Phase 1 clinical trial to evaluate the drug in healthy volunteers and patients with sickle cell disease.

What phase is BMS-986470 in?

BMS-986470 is in Phase 1 clinical development. It is an investigational drug, meaning it has not been approved by regulatory authorities and is still being studied in clinical trials. The ongoing Phase 1 study is recruiting participants with sickle cell disease and healthy volunteers.

What clinical trials is BMS-986470 in?

BMS-986470 is being studied in a Phase 1 clinical trial with the identifier NCT06481306. This randomized, double-blind, controlled study is evaluating the drug in healthy volunteers and participants with sickle cell disease, with an enrollment target of 224 participants across the United States, Canada, France, Italy, and the United Kingdom.

Is BMS-986470 being studied in healthy volunteers?

Yes, BMS-986470 is being studied in healthy volunteers as part of its Phase 1 clinical trial. The study, NCT06481306, includes healthy volunteers as well as participants with sickle cell disease, and is designed to evaluate the drug's safety and tolerability in both groups.