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BMS-986447

Phase 1

Undisclosed | Small molecule | Other |Bristol-Myers Squibb Company|Trials Updated: Apr 5, 2024

BMS-986447 development status

Highest phase Phase 1
Registered trials 1 across 1 sponsor since Mar 2023

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindPLACEBO_CONTROLLED
Total Trials1
Total Enrollment32

FDA Designations

No designations recorded

BMS-986447 clinical trials

BMS-986447 · 1 trial · 1 indication

Phase 1 1
NCT05760937A Study to Evaluate the Safety, Tolerability and Drug Levels of BMS-986447 in Healthy ParticipantsHealthy Participants
COMPLETED32 Analytics
PHASE1COMPLETED
A Study to Evaluate the Safety, Tolerability and Drug Levels of BMS-986447 in Healthy Participants
Healthy ParticipantsUnlock trial analytics

Study Endpoints

Primary Endpoints

Number of Participants with Adverse Events (AEs)
Up to 59 days
Number of Participants with Serious AEs (SAEs)
Up to 59 days
Number of Participants with Clinical Laboratory Abnormalities
Up to 34 days
Number of Participants with Vital Sign Abnormalities
Up to 35 days
Number of Participants with Physical Examination Abnormalities
Up to 35 days
Number of Participants with Electrocardiogram (ECG) Abnormalities
Up to 34 days

Secondary Endpoints

Maximum observed plasma concentration (Cmax)
Up to 72 hours postdose
Time of maximum observed plasma concentration (Tmax)
Up to 72 hours postdose
Apparent terminal phase half-life (T-Half)
Up to 72 hours postdose
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Study Design & Arms

AllocationRANDOMIZED
MaskingTRIPLE
ModelSEQUENTIAL
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
BMS-986447EXPERIMENTAL -
PlaceboPLACEBO_COMPARATOR -

Interventions

NameTypeDescription
BMS-986447DRUGSpecified dose on specified days
PlaceboDRUGSpecified dose on specified days
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Eligibility Criteria

Age Range18 Years to 55 Years
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * Body mass index between 18 and 30 kilograms per metered square (kg/m\^2), inclusive. * Healthy male and female participants without clinically significant deviation from normal in medical history, physical examination, ECG, and clinical laboratory determinations. * A negative ...

Countries:United States
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Frequently asked questions about BMS-986447

What is BMS-986447?

BMS-986447 is an investigational small molecule drug being developed by Bristol-Myers Squibb Company (ticker: BMY). It has been studied in a Phase 1 clinical trial in healthy participants. The therapeutic indication for BMS-986447 has not been disclosed.

Who makes BMS-986447?

BMS-986447 is being developed by Bristol-Myers Squibb Company, which trades under the ticker BMY. Bristol-Myers Squibb sponsored the Phase 1 study of BMS-986447 conducted in the United States.

What phase is BMS-986447 in?

BMS-986447 is in Phase 1 clinical development. It is an investigational drug and has not been approved by the FDA. One Phase 1 trial of BMS-986447 has been completed, and no trials of the drug are currently active.

What clinical trials is BMS-986447 in?

BMS-986447 has been evaluated in one clinical trial, NCT05760937, titled A Study to Evaluate the Safety, Tolerability and Drug Levels of BMS-986447 in Healthy Participants. The Phase 1 trial enrolled 32 healthy participants in the United States and is completed.

How was the BMS-986447 Phase 1 trial designed?

The Phase 1 trial of BMS-986447, NCT05760937, was a randomized, double-blind, placebo-controlled study in healthy participants aged 18 years and older. It enrolled 32 participants in the United States and assessed safety, tolerability, and drug levels of BMS-986447.