Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
| NCT ID | Title | Phase | Status | Enrollment | Velocity | Design | Start | Completion | Last Updated | Sites | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|
| NCT04550195 | A Study to Evaluate the Safety, Tolerability, and Drug Levels of BMS-986337 When Taken by Mouth by Healthy Participants | PHASE1 | COMPLETED | 26 | — | — | Sep 17, 2020 | Mar 3, 2021 | Feb 25, 2022 | 1 | Netherlands |
PR interval is the time from the onset of the P wave to the start of the QRS complex
QRS can be defined as the electrical impulse as it spreads through the ventricles, indicating ventricular depolarization
QTcF = Corrected QT interval using the Fridericia formula. QT interval is the time from the start of the Q wave to the end of the T wave.
The QT interval is the time from the start of the Q wave to the end of the T wave.
| Arm | Type | Description |
|---|---|---|
| Part A Single Ascending Dose (SAD) Cohort A1 | EXPERIMENTAL | - |
| Part A SAD Cohort A2 | EXPERIMENTAL | - |
| Part A SAD Cohort A3 | EXPERIMENTAL | - |
| Part A SAD Cohort A4 | EXPERIMENTAL | - |
| Part A SAD Cohort A5 | EXPERIMENTAL | - |
| Part A SAD Cohort A6 | EXPERIMENTAL | - |
| Part B Multiple Ascending Dose (MAD) Cohort B1 | EXPERIMENTAL | - |
| Part B MAD Cohort B2 | EXPERIMENTAL | - |
| Part B MAD Cohort B3 | EXPERIMENTAL | - |
| Part B MAD Cohort B4 | EXPERIMENTAL | - |
| Part C MAD in Japanese Healthy participants Cohort C1 | EXPERIMENTAL | - |
| Part C MAD in Japanese Healthy participants Cohort C2 | EXPERIMENTAL | - |
| Part C MAD in Japanese Healthy participants Cohort C3 | EXPERIMENTAL | - |
| Name | Type | Description |
|---|---|---|
| BMS-986337 | DRUG | Specified Dose on Specified Days |
| BMS-986337 Placebo | OTHER | Specified Dose on Specified Days |
| Famotidine | BIOLOGICAL | Specified Dose on Specified Days |
Inclusion Criteria: * No clinically significant deviation from normal in medical history, physical examination, electrocardiograms (ECGs), and clinical laboratory determinations * For Japanese cohorts in Part C, must be first-generation Japanese (born in Japan, not living outside of Japan for more ...