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BMS-816336

Phase 1

Diabetes Mellitus, Non-Insulin-Dependent | Small molecule | Metabolic |Bristol-Myers Squibb Company|Last Updated: Feb 23, 2011

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindACTIVE_CONTROLLEDBiomarker
Total Trials1
Total Enrollment40
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00979368Safety Study of BMS-816336 in Healthy Male SubjectsPHASE1 COMPLETED 40Nov 1, 2009Feb 1, 2010Feb 23, 20111 Australia
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Study Endpoints
Primary Endpoints
Exposure to the investigational drug will be measured to assess safety and tolerability
Within 72 hours following dosing
Secondary Endpoints
To assess the single dose Pharmacokinetics of BMS-816336
During 72 hours following dosing
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Study Design & Arms
AllocationRANDOMIZED
MaskingTRIPLE
ModelPARALLEL
Treatment Arms
ArmTypeDescription
BMS-816336 or placebo (Panel 1)ACTIVE_COMPARATOR -
BMS-816336 or placebo (Panel 2)ACTIVE_COMPARATOR -
BMS-816336 or placebo (Panel 3)ACTIVE_COMPARATOR -
BMS-816336 or placebo (Panel 4)ACTIVE_COMPARATOR -
BMS-816336 or placebo (Panel 5)ACTIVE_COMPARATOR -
Interventions
NameTypeDescription
BMS-816336DRUGSuspension, Oral, 15 mg Active, Once on Day 1 only, 4 days
PlaceboDRUGSuspension, Oral, 0 mg, Once on Day 1 only, 4 days
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Eligibility Criteria
Age Range18 Years — 55 Years
SexMALE
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * Healthy male subjects * BMI of 18 to 32 kg/m² * Men only, ages 18-55 years Exclusion Criteria: * Sexually active men not using effective birth control if their partners are WOCBP * Any significant acute or chronic medical illness * Family history of Gilbert's disease * Histo...

Countries:Australia
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