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LBS-008

Phase 1

Healthy Volunteer | Small molecule | Other |Belite Bio, Inc|Last Updated: Jan 7, 2020

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindCONTROLLEDDMCBiomarker
Total Trials1
Total Enrollment71
FDA Designations
FAST_TRACK
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT03735810Safety and Tolerability Study of LBS-008 in Healthy Adult Subjects After Single and Multiple DosesPHASE1 COMPLETED 71Nov 15, 2018Sep 16, 2019Jan 7, 20201 Australia
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Study Endpoints
Primary Endpoints
Area under the plasma concentration versus time curve from time 0 to the last timepoint with quantifiable concentration (AUC0-t)
SAD portion: Day 1 to Day 8; MAD portion: Day 1 to Day 28
Area under the plasma concentration versus time curve from time 0 extrapolated to infinity (AUC0-inf)
SAD portion: Day 1 to Day 8; MAD portion: Day 1 to Day 28
Maximum observed plasma concentration (Cmax)
SAD portion: Day 1 to Day 6; MAD portion: Day 1 to Day 28
Time to maximum observed plasma concentration (Tmax)
SAD portion: Day 1 to Day 8; MAD portion: Day 1 to Day 28
Terminal elimination rate constant
SAD portion: Day 1 to Day 8; MAD portion: Day 1 to Day 28
Terminal phase half-life (t1/2)
SAD portion: Day 1 to Day 8; MAD portion: Day 1 to Day 28
Apparent total body clearance (CL/F)
SAD portion: Day 1 to Day 8; MAD portion: Day 1 to Day 28
Apparent volume of distribution (Vz/F)
SAD portion: Day 1 to Day 8; MAD portion: Day 1 to Day 28
Number of participants with Adverse Events (AEs), Serious Adverse Events (SAEs) and AEs leading to discontinuation.
SAD portion: Day 1 to Day 8; MAD portion: Day 1 to Day 28
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Study Design & Arms
AllocationRANDOMIZED
MaskingDOUBLE
ModelSEQUENTIAL
PurposeBASIC_SCIENCE
Treatment Arms
ArmTypeDescription
SAD - Cohort 1EXPERIMENTAL50 mg LBS-008 or placebo
SAD - Cohort 2EXPERIMENTAL100 mg LBS-008 or placebo
SAD - Cohort 3EXPERIMENTAL200 mg LBS-008 or placebo
SAD - Cohort 4EXPERIMENTAL400 mg LBS-008 or placebo
SAD - Cohort 5EXPERIMENTAL25 mg LBS-008 or placebo
MAD - Cohort 1EXPERIMENTAL10 mg LBS-008 or placebo
MAD - Cohort 2EXPERIMENTAL25 mg LBS-008 or placebo
MAD - Cohort 3EXPERIMENTAL5 mg LBS-008 or placebo
MAD - Cohort 4EXPERIMENTAL12 mg LBS-008 or placebo
Interventions
NameTypeDescription
LBS-008DRUGLBS-008 oral capsules
PlacebosDRUGOral capsules
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Eligibility Criteria
Age Range18 Years — 65 Years
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * The subject is male or female, 18 to 65 years of age, inclusive, at screening. * The subject voluntarily consents to participate in this study and provides written informed consent before the start of any study-specific procedures. * The subject is willing and able to remain i...

Countries:Australia
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