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Rifaximin SSD IR

Phase 1

Dementia Alzheimer Type | Small molecule | Neurology |Bausch + Lomb Corporation|Last Updated: Apr 3, 2026

Success Probability

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Market & Valuation

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Trial Design

Double-BlindPLACEBO_CONTROLLED
Total Trials1
Total Enrollment20

FDA Designations

No designations recorded

Clinical trial landscape

Rifaximin SSD IR · 1 trial · 2 indications

Phase 1 1
NCT06718686Rifaximin SSD in Dementia TrialDementia Alzheimer Type
RECRUITING20 Analytics
PHASE1RECRUITING
Rifaximin SSD in Dementia Trial
Dementia Alzheimer TypeUnlock trial analytics

Study Endpoints

Primary Endpoints

Change in stool and serum short-chain fatty acid levels
10 weeks

Change in SCFA in stool and serum in rifaximin SSD phase vs placebo phase

Change in bile acids in stool and serum
10 weeks

Change in bile acids in stool and serum in rifaximin SSD phase vs placebo phase

Secondary Endpoints

Systemic inflammatory change
10 weeks
Stool microbiome composition
10 weeks
Change in dementia biomarkers
10 weeks
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Study Design & Arms

AllocationNA
MaskingTRIPLE
ModelSEQUENTIAL
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
PlaceboPLACEBO_COMPARATORPatients will be given placebo and actual drug sequentially with the order hidden
Rifaximin SSD 40mg IR BIDEXPERIMENTALPatients will be given placebo and actual drug sequentially with the order hidden

Interventions

NameTypeDescription
Rifaximin SSD 40 mg IR tabletDRUGDrug therapy vs placebo
PlaceboDRUGPlacebo drug
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Eligibility Criteria

Age Range65 Years to N/A
SexALL
Healthy VolunteersNo
Study Sites1

Inclusion Criteria: * Probable Alzheimer's Disease (AD) or Vascular Dementia (VaD) mild or moderate based on Clinical Dementia Rating Scale. * Males and Females Age ≥ 65 years * Community living with availability of caregiver to accompany participant to study visits and to participate in the study....

Countries:United States
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Frequently asked questions about Rifaximin SSD IR

What is Rifaximin SSD IR used for?

Rifaximin SSD IR is an investigational small molecule being studied for dementia of the Alzheimer type. It is currently in Phase 1 clinical development for this neurological condition. The drug is being evaluated in a clinical trial that also includes patients with dementia associated with cerebrovascular disease.

Who makes Rifaximin SSD IR?

Rifaximin SSD IR is being developed by Bausch + Lomb Corporation, which trades under the ticker BLCO. The company is conducting a Phase 1 clinical trial of the drug in the United States for dementia of the Alzheimer type.

What phase is Rifaximin SSD IR in?

Rifaximin SSD IR is in Phase 1 clinical development. It is an investigational drug and has not been approved by the FDA. The ongoing Phase 1 trial is currently recruiting participants in the United States.

What clinical trials is Rifaximin SSD IR in?

Rifaximin SSD IR is being studied in a Phase 1 clinical trial with the identifier NCT06718686, titled "Rifaximin SSD in Dementia Trial." The trial is recruiting 20 participants aged 65 years and older in the United States and is double-blind and placebo-controlled.

Is Rifaximin SSD IR the same as Rifaximin SSD 40 mg IR tablet?

Yes, Rifaximin SSD IR is also known as Rifaximin SSD 40 mg IR tablet. Both names refer to the same investigational drug being developed by Bausch + Lomb Corporation for dementia of the Alzheimer type.

How does Rifaximin SSD IR work?

Rifaximin SSD IR is a small molecule being studied for dementia of the Alzheimer type. The specific molecular target of the drug has not been disclosed in the available clinical trial information, so its mechanism of action is not described here.