Recent Updates
Recently added Catalysts

Ocular BL1332 low dose

Phase 2

Pain, Postoperative | Small molecule | Pain |Bausch + Lomb Corporation|Last Updated: Feb 17, 2026

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
Premium
Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
Premium
Trial Design
RandomizedDouble-BlindPLACEBO_CONTROLLEDBiomarker
Total Trials1
Total Enrollment123
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT07412496A Study to Evaluate the Use of Topical Ocular BL1332 for the Management of Postoperative Ocular Pain Following Photorefractive KeratectomyPHASE2 NOT YET_RECRUITING 123Apr 1, 2026Feb 1, 2027Feb 17, 2026 -
Unlock Drug Trial Details
Study Endpoints
Primary Endpoints
Ocular pain intensity following PRK surgery
Assessed at a 24-hour period following PRK surgery

Ocular pain intensity assessed using numeric pain rating scale 0 to 10, with 10 being the worst pain

Secondary Endpoints
Ocular pain intensity postoperative period following PRK surgery
Assessed at a 12-hour postoperative period following PRK surgery
Unlock Study Endpoints
Study Design & Arms
AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
Topical Ocular BL1332 low doseEXPERIMENTALBL1332 low dose ocular drop used 5x daily
Topical Ocular BL1332 high doseEXPERIMENTALBL1332 high dose ocular drop used 5x daily
BL1332 ophthalmic vehiclePLACEBO_COMPARATORBL1332 vehicle ocular drop used 5x daily
Interventions
NameTypeDescription
Topical Ocular BL1332 low doseDRUGAdministered 5 times a day
Topical Ocular BL1332 high doseDRUGAdministered 5 times a day
BL1332 Vehicle ophthalmic vehicleDRUGAdministered 5 times a day
Unlock Study Design Details
Eligibility Criteria
Age Range18 Years — 58 Years
SexALL
Healthy VolunteersNo

Inclusion Criteria: 1. Male or female 18 to 58 years of age, inclusive. 2. Scheduled to undergo PRK surgery and considered to be a good candidate per the Investigator's discretion. 3. Provide written informed consent (signed and dated informed consent form \[ICF\]) using the Institutional Review Bo...

Unlock Eligibility Criteria
Recent Changes (Last 90 Days)
LOWMay 26, 2026NCT07412496primaryCompletionDate: changed
LOWMay 24, 2026NCT07412496studyFirstPostDate: changed