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KetoNaph

Phase 3

Allergic Conjunctivitis | Small molecule | Other |Bausch + Lomb Corporation|Last Updated: Oct 5, 2020

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindPLACEBO_CONTROLLEDBiomarker
Total Trials1
Total Enrollment534
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT01159015Study Evaluating the Safety of KetoNaph Ophthalmic Solution in Healthy VolunteersPHASE3 COMPLETED 534Jul 1, 2010Oct 1, 2010Oct 5, 2020 -
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Study Endpoints
Primary Endpoints
Percentage of Participants With at Least One Adverse Event.
42 days

An adverse event was defined as unfavorable and unintended sign, symptom, or disease temporally associated with the use of a test article, whether or not considered related to test article.

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Study Design & Arms
AllocationRANDOMIZED
MaskingTRIPLE
ModelPARALLEL
PurposeSCREENING
Treatment Arms
ArmTypeDescription
KetoNaphEXPERIMENTALKetoNaph Ophthalmic Solution
VehiclePLACEBO_COMPARATORVehicle of KetoNaph Ophthalmic Solution
Interventions
NameTypeDescription
KetoNaphDRUGOphthalmic Solution administered BID for 6 weeks
VehicleDRUGVehicle of KetoNaph ophthalmic solution administered bid for six weeks
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Eligibility Criteria
Age Range2 Years — N/A
SexALL
Healthy VolunteersYes

Inclusion Criteria: * Subjects less than 18 years of age, have either a history or family history of ocular allergy. * ocular health within normal limits, including a calculated best-corrected visual acuity of 0.3 logMar or better, in each eye. For subjects under 10 years old who are developmentall...

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