Recent Updates
Recently added Catalysts

Gatifloxacin

Phase 1

Healthy | Small molecule | Other |Bausch + Lomb Corporation|Last Updated: Dec 9, 2011

Success Probability

Subscribe to view

Market & Valuation

Subscribe to view

Trial Design

RandomizedDouble-BlindACTIVE_CONTROLLED
Total Trials1
Total Enrollment119

FDA Designations

No designations recorded

Clinical trial landscape

Gatifloxacin · 1 trial · 1 indication

Phase 1 1
NCT00905762Concentration of Besifloxacin, Gatifloxacin, and Moxifloxacin in Human Conjunctiva After Topical InstillationHealthy
COMPLETED119 Analytics
PHASE1COMPLETED
Concentration of Besifloxacin, Gatifloxacin, and Moxifloxacin in Human Conjunctiva After Topical Instillation
HealthyUnlock trial analytics

Study Endpoints

Primary Endpoints

Concentration of besifloxacin, gatifloxacin or moxifloxacin in conjunctival tissue.
Biopsies collected at specified time points from 15 minutes to 24 hours

Secondary Endpoints

Visual acuity
Day -14 through Day 6(+/-1)
Slit Lamp Biomicroscopy
Day -14 through Day 6 (+/-)
Unlock Study Endpoints

Study Design & Arms

AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeSCREENING

Treatment Arms

ArmTypeDescription
BesifloxacinEXPERIMENTALBesifloxacin one drop instilled into study eye.
GatifloxacinACTIVE_COMPARATORGatifloxacin one drop instilled into study eye.
MoxifloxacinACTIVE_COMPARATORMoxifloxacin one drop instilled into study eye.

Interventions

NameTypeDescription
GatifloxacinDRUGGatifloxacin 0.3% one drop instilled into study eye at visit 2.
MoxifloxacinDRUGMoxifloxacin 0.5% one drop instilled into study eye at visit 2.
BesifloxacinDRUGBesifloxacin 0.6% one drop instilled into study eye at visit 2.
Unlock Study Design Details

Eligibility Criteria

Age Range18 Years to N/A
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * Willing to avoid all disallowed medications for the appropriate washout periods. * Have a best corrected visual acuity of 0.60 logMAR or better in each eye as measured using an ETDRS chart. Exclusion Criteria: * Have a known allergy and/or sensitivity to the test articles or...

Countries:United States
Unlock Eligibility Criteria

Frequently asked questions about Gatifloxacin

What is Gatifloxacin?

Gatifloxacin is a small molecule drug being developed by Bausch + Lomb Corporation (BLCO). It is currently in Phase 1 clinical development. Gatifloxacin is an antibiotic that has been studied for its concentration in human conjunctiva after topical instillation.

What is Gatifloxacin used for?

Gatifloxacin is being studied for use in healthy volunteers to measure its concentration in the human conjunctiva after topical instillation. The drug is in Phase 1 clinical development for this purpose. It is not yet approved for any indication.

Who makes Gatifloxacin?

Gatifloxacin is being developed by Bausch + Lomb Corporation, which trades under the ticker BLCO. The company is conducting clinical research on this small molecule drug, which is currently in Phase 1 development.

What phase is Gatifloxacin in?

Gatifloxacin is in Phase 1 clinical development. It is an investigational drug and has not been approved by regulatory authorities. The drug is being studied in a clinical trial to evaluate its concentration in human conjunctiva after topical instillation.

What clinical trials is Gatifloxacin in?

Gatifloxacin is associated with one completed Phase 1 clinical trial, NCT00905762, titled "Concentration of Besifloxacin, Gatifloxacin, and Moxifloxacin in Human Conjunctiva After Topical Instillation." The trial enrolled 119 healthy participants in the United States and was double-blind with an active control.

Is Gatifloxacin the same as Besifloxacin or Moxifloxacin?

Gatifloxacin is a distinct drug from Besifloxacin and Moxifloxacin, though they were studied together in a clinical trial. The trial NCT00905762 compared the concentration of these three antibiotics in human conjunctiva after topical instillation. Each is a separate fluoroquinolone antibiotic.