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Besivance

Phase 3

Bacterial Conjunctivitis | Small molecule | Infectious Disease |Bausch + Lomb Corporation|Last Updated: May 1, 2013

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindPLACEBO_CONTROLLED
Total Trials1
Total Enrollment518
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT01175590Safety of Besivance™ (Besifloxacin Ophthalmic Suspension) 0.6% Compared to VehiclePHASE3 COMPLETED 518Jun 1, 2010Feb 1, 2012May 1, 20131 United States
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Study Endpoints
Primary Endpoints
Ocular Treatment Emergent Adverse Events
At each visit - 7 days

Ocular Treatment-Emergent Adverse Events on the Study Eye

Non-Ocular Treatment-Emergent Adverse Events
7 days

Non-Ocular Treatment-Emergent Adverse Events on the Study Eye

Secondary Endpoints
Clinical Resolution
Day 8 (Visit 2)
Microbial Eradication
Days 8 (Visit 2)
Microbial Outcome With Clinical Resolution
Day 8 (Visit 2)
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Study Design & Arms
AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
BesivanceEXPERIMENTALbesifloxacin ophthalmic suspension 0.6%
VehiclePLACEBO_COMPARATORVehicle of Besivance
Interventions
NameTypeDescription
BesivanceDRUGOcular administration to affected eye for 7 days
VehicleDRUGVehicle of Besivance administered to affected eye for 7 days
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Eligibility Criteria
Age Range1 Year — N/A
SexALL
Healthy VolunteersNo
Study Sites1

Inclusion Criteria: * Subjects must have a clinical diagnosis of acute bacterial conjunctivitis and exhibit purulent conjunctival discharge (crusty or sticky eyelids) and redness in at least one eye. * Subjects who are willing to discontinue contact lens wear for the duration of the study. * Subjec...

Countries:United States
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