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CDP7657

Phase 1

Immune System Diseases | Monoclonal antibody | Immunology |Biogen Inc.|Last Updated: Jul 16, 2015

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedPLACEBO_CONTROLLEDDMC
Total Trials1
Total Enrollment24
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT01764594Safety Study of CDP7657 in Patients With Systemic Lupus ErythematosusPHASE1 COMPLETED 24Jan 1, 2013Aug 1, 2014Jul 16, 201521 Belgium, Bulgaria +5
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Study Endpoints
Primary Endpoints
Percentage of subjects with at least one Treatment-emergent Adverse Event (TEAE) during the study
0 - 28 Weeks
Percentage of subjects who withdrew due to an Treatment-emergent Adverse Event (TEAE) during the study
0 - 28 Weeks
Secondary Endpoints
Maximum plasma concentration (Cmax)
0 - 28 Weeks
Predose plasma concentration (Ctrough)
0 - 28 Weeks
Area under the concentration-time curve over the dosing interval (AUCτ)
0 - 28 Weeks
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Study Design & Arms
AllocationRANDOMIZED
MaskingSINGLE
ModelPARALLEL
Treatment Arms
ArmTypeDescription
CDP7657EXPERIMENTALCDP7657 100 mg/ ml solution 30 mg/ kg initial dose 15 mg/ kg every other week 10 weeks
PlaceboPLACEBO_COMPARATORPlacebo
Interventions
NameTypeDescription
CDP7657BIOLOGICALCDP7657 100 mg/ ml solution 30 mg/ kg initial dose 15 mg/ kg every other week 10 weeks
PlaceboOTHERPlacebo comparator
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Eligibility Criteria
Age Range18 Years — 75 Years
SexALL
Healthy VolunteersNo
Study Sites21

Inclusion Criteria: * Patients with Systemic Lupus Erythematosus (SLE) Exclusion Criteria: * Severe neuropsychiatric or severe renal Systemic Lupus Erythematosus (SLE) * History of chronic, recurrent, or recent severe infection * Significant hematologic abnormalities * History of cancer, heart fa...

Countries:BelgiumBulgariaGermanyPolandRomaniaRussiaSpain
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