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BIIB144

Phase 1

Healthy Volunteer | Small molecule | Other |Biogen Inc.|Last Updated: Jul 27, 2026

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindCONTROLLEDDMC
Total Trials1
Total Enrollment48

FDA Designations

No designations recorded

Clinical trial landscape

BIIB144 · 1 trial · 1 indication

Phase 1 1
NCT07662148A Study to Learn More About the Safety of a Single Dose of BIIB144 and How it is Processed in the Body of Healthy Adult Participants Ages 18 to 55 Years Old as Compared to a PlaceboHealthy Volunteer
RECRUITING48 Analytics
PHASE1RECRUITING
A Study to Learn More About the Safety of a Single Dose of BIIB144 and How it is Processed in the Body of Healthy Adult Participants Ages 18 to 55 Years Old as Compared to a Placebo
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Study Endpoints

Primary Endpoints

Number of Participants With Treatment Emergent Adverse Events (TEAEs) and Serious Adverse Events (SAEs)
Up to Day 280

Secondary Endpoints

Area Under the Serum Concentration-Time Curve From Time Zero to Time of the Last Measurable Concentration (AUC0-last) of BIIB144
Pre-dose and at multiple time points post-dose up to Day 280
Area Under the Serum Concentration-Time Curve From Time Zero to Infinity (AUC0-inf) of BIIB144
Pre-dose and at multiple time points post-dose up to Day 280
Maximum Observed Serum Concentration (Cmax) of BIIB144
Pre-dose and at multiple time points post-dose up to Day 280
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Study Design & Arms

AllocationRANDOMIZED
MaskingQUADRUPLE
ModelSEQUENTIAL
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
BIIB144 Cohort 1EXPERIMENTALParticipants will receive Dose A of BIIB144 or a matching placebo via intravenous (IV) infusion on Day 1.
BIIB144 Cohort 2EXPERIMENTALParticipants will receive Dose B of BIIB144 or a matching placebo via IV infusion on Day 1.
BIIB144 Cohort 3EXPERIMENTALParticipants will receive Dose C of BIIB144 or a matching placebo via IV infusion on Day 1.
BIIB144 Cohort 4EXPERIMENTALParticipants will receive Dose D of BIIB144 or a matching placebo via IV infusion on Day 1.
BIIB144 Cohort 5EXPERIMENTALParticipants will receive Dose E of BIIB144 or a matching placebo via IV infusion on Day 1.
BIIB144 Cohort 6EXPERIMENTALParticipants will receive Dose F of BIIB144 or a matching placebo via IV infusion on Day 1.

Interventions

NameTypeDescription
BIIB144DRUGAdministered IV
PlaceboDRUGAdministered IV
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Eligibility Criteria

Age Range18 Years to 55 Years
SexALL
Healthy VolunteersYes
Study Sites1

Key Inclusion Criteria: * Have a body mass index (BMI) between 18 and 32 kilograms per square metre (kg/m\^2), inclusive, at Screening. * Must be in good health as determined by the Investigator, based on medical history and Screening evaluations. Key Exclusion Criteria: * History of any clinical...

Countries:United States
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Recent Changes (Last 90 Days)

LOWJul 27, 2026NCT07662148Status: NOT_YET_RECRUITING → RECRUITING
LOWJul 27, 2026NCT07662148Status: NOT_YET_RECRUITING → RECRUITING
LOWJul 27, 2026NCT07662148Status: NOT_YET_RECRUITING → RECRUITING
LOWJun 23, 2026NCT07662148NEW_TRIAL: changed
LOWJun 23, 2026NCT07662148NEW_TRIAL: changed

Frequently asked questions about BIIB144

What is BIIB144 used for?

BIIB144 is an investigational small molecule being studied in healthy volunteers. It is currently in a Phase 1 clinical trial to evaluate the safety of a single dose and how it is processed in the body of healthy adult participants aged 18 to 55 years, compared to a placebo.

Who makes BIIB144?

BIIB144 is being developed by Biogen Inc., a biopharmaceutical company traded on the NASDAQ under the ticker symbol BIIB. The company is conducting a Phase 1 clinical trial of BIIB144 in healthy volunteers in the United States.

What phase is BIIB144 in?

BIIB144 is in Phase 1 clinical development. It is an investigational drug, meaning it has not been approved by regulatory authorities. The ongoing Phase 1 study is recruiting participants to assess the safety and pharmacokinetics of a single dose of BIIB144 compared to placebo.

What clinical trials is BIIB144 in?

BIIB144 is being studied in one active Phase 1 clinical trial with the identifier NCT07662148. This randomized, double-blind, placebo-controlled study is enrolling 48 healthy adult participants aged 18 to 55 years in the United States to evaluate the safety and how the drug is processed in the body.

Is BIIB144 a small molecule?

Yes, BIIB144 is a small molecule drug. It is being developed by Biogen Inc. and is currently in a Phase 1 clinical trial in healthy volunteers to assess its safety and pharmacokinetics following a single dose.